DigSee: Disease gene search engine with evidence sentences (version cancer).

DigSee: Disease gene search engine with evidence sentences (version cancer).
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DOI:
10.1093/nar/gkt531
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发表时间:
2013-07
影响因子:
14.9
通讯作者:
Lee H
Lee H
中科院分区:
生物学2区
文献类型:
--
作者:
Kim J;So S;Lee HJ;Park JC;Kim JJ;Lee H

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基因表达、调控、磷酸化、定位和蛋白质分解代谢等生物事件在疾病的发生发展中发挥着重要作用。了解疾病和基因之间的关联可以通过识别这种关联中涉及的生物学事件来加强。虽然生物知识已经积累在几个数据库中,并且可以通过网络访问,但是还没有专门的网络工具允许查询疾病、基因和生物事件之间的关系。为了完成这项任务,我们开发了DigSee来搜索MEDLINE摘要,寻找描述“基因”通过“生物事件”参与“癌症”发展的证据句子。DigSee可通过http://gcancer.org/digsee获得。
Biological events such as gene expression, regulation, phosphorylation, localization and protein catabolism play important roles in the development of diseases. Understanding the association between diseases and genes can be enhanced with the identification of involved biological events in this association. Although biological knowledge has been accumulated in several databases and can be accessed through the Web, there is no specialized Web tool yet allowing for a query into the relationship among diseases, genes and biological events. For this task, we developed DigSee to search MEDLINE abstracts for evidence sentences describing that ‘genes’ are involved in the development of ‘cancer’ through ‘biological events’. DigSee is available through http://gcancer.org/digsee.
DOI: 10.1093/nar/gkn760
发表时间: 2009-01
影响因子: 14.9
作者:
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发表时间: 2009-01-01
期刊: METHODS IN BIOENGINEERING: SYSTEMS ANALYSIS OF BIOLOGICAL NETWORKS
影响因子: --
作者:
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