HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail.
HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail.
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HOXA7 在与 Snail 激活相关的肝癌转移中发挥关键作用
DOI：
10.1186/s12943-016-0540-4
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发表时间：
2016-09-06
期刊：
影响因子：
37.3
通讯作者：
He S
中科院分区：
文献类型：
--
作者：
Tang B;Qi G;Sun X;Tang F;Yuan S;Wang Z;Liang X;Li B;Yu S;Liu J;Huang Q;Wei Y;Zhai R;Lei B;Guo X;He S
肝癌是人类癌症相关死亡的主要原因之一。 HOXA7已被证明与多种癌症有关。通过Western blot、qRT-PCR或ICH检查HOXA7的表达水平。采用MTT法检测肝癌细胞的增殖率。通过基质胶和Transwell实验检测侵袭能力。在BALB/c裸鼠中揭示了肝癌细胞的转移能力。在本报告中，我们揭示了 HOXA7 促进 HCC 患者的转移。首先，在肝癌尤其是转移性肝癌中检测了 HOXA7 水平升高。此外，HOXA7表达水平较高与肝癌患者预后较差相关。 HOXA7过表达显着增强体外增殖、迁移、侵袭和体内肿瘤生长和转移能力，而沉默HOXA7则显着抑制肝癌细胞的上述能力。在这项研究中，我们发现 HOXA7 通过激活 Snail 发挥其致癌特性。总的来说，我们确定了 HOXA7 在肝癌转移中的关键作用和可能机制，这表明 HOXA7 可能是肝癌患者的潜在治疗靶点。本文的在线版本 (doi:10.1186/s12943-016-0540-4) 包含补充材料，可供授权用户使用。
Liver cancer is one of the main causes of cancer-related death in human. HOXA7 has been proved to be related with several cancers. The expression levels of HOXA7 were examined by Western blot, qRT-PCR or ICH. MTT was used to detect the proliferative rate of liver cancer cells. The invasive abilities were examined by matrigel and transwell assay. The metastatic abilities of liver cancer cells were revealed in BALB/c nude mice. In this report, we revealed that HOXA7 promoted metastasis of HCC patients. First, increased levels of HOXA7 were examined in liver cancer especially in metastatic liver cancer. Moreover, higher expression level of HOXA7 was associated with poorer prognosis of liver cancer patients. Overexpression of HOXA7 significantly enhanced proliferation, migration, invasion in vitro and tumor growth and metastasis in vivo meanwhile silencing HOXA7 significantly inhibited the aboves abilities of liver cancer cells. In this research, we identified that HOXA7 performed its oncogenic characteristics through activating Snail. Collectively, we identify the critical role and possible mechanism of HOXA7 in metastasis of liver cancer which suggest that HOXA7 may be a potential therapeutic target of liver cancer patients. The online version of this article (doi:10.1186/s12943-016-0540-4) contains supplementary material, which is available to authorized users.
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影响因子：
11.2
作者：
Onder, Tamer T.;Gupta, Piyush B.;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.
DOI：
10.1186/bcr2938
发表时间：
2012-01-19
期刊：
Breast cancer research : BCR
影响因子：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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Sukumar, S
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
64.5
作者：
Ang YS;Tsai SY;Lee DF;Monk J;Su J;Ratnakumar K;Ding J;Ge Y;Darr H;Chang B;Wang J;Rendl M;Bernstein E;Schaniel C;Lemischka IR
通讯作者：
Lemischka IR