Interindividual variability in response to continuous theta-burst stimulation in healthy adults.
Interindividual variability in response to continuous theta-burst stimulation in healthy adults.
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DOI：
10.1016/j.clinph.2017.08.023
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发表时间：
2017-11
期刊：
影响因子：
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通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
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作者：
Jannati A;Block G;Oberman LM;Rotenberg A;Pascual-Leone A
我们使用完全连锁聚类分析，以确定健康亚群与不同的反应，连续θ-突发刺激（cTBS）。21例健康成人（年龄±SD，36.9±15.2岁）行左侧运动皮质cTBS检查。计算cTBS后5-50分钟（T5-T50）的自然对数转换运动诱发电位（LnMEPs）。发现两个集群;第1组（n=12）在T15、T20和T50显示出显著的MEP易化（p <.006），第2组（n=9）在T5-T15显示出显著的抑制（p <.022）。T10和T40的LnMEP是聚类分配的最佳预测因子，并且一起占聚类分配的80%。在探索性分析中，我们研究了脑源性神经营养因子（BDNF）和载脂蛋白E（APOE）多态性在cTBS反应中的作用。Val 66 Met参与者在T10时比Val 66 Val参与者表现出更大的易化性（p=.025）。BDNF和cTBS强度预测59%的个体间变异LnMEP在T10。APOE在任何时间点均未显著影响LnMEP（p> 0.32）。数据驱动的聚类分析可以识别具有不同cTBS应答的健康亚群。T10和T40 LnMEP是聚类分配的最佳预测因子。T10 LnMEP受BDNF基因多态性和cTBS强度的影响。健康成年人可以被分成具有受遗传学影响的不同cTBS反应的亚群。
We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS). 21 healthy adults (age±SD, 36.9±15.2 years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5–50 minutes post-cTBS (T5–T50) were calculated. Two clusters were found; Group 1 (n=12) that showed significant MEP facilitation at T15, T20, and T50 (p’s<.006), and Group 2 (n=9) that showed significant suppression at T5–T15 (p’s<.022). LnMEPs at T10 and T40 were best predictors of, and together accounted for 80% of, cluster assignment. In an exploratory analysis, we examined the roles of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms in the cTBS response. Val66Met participants showed greater facilitation at T10 than Val66Val participants (p=.025). BDNF and cTBS intensity predicted 59% of interindividual variability in LnMEP at T10. APOE did not significantly affect LnMEPs at any time point (p’s>.32). Data-driven cluster analysis can identify healthy subpopulations with distinct cTBS responses. T10 and T40 LnMEPs were best predictors of cluster assignment. T10 LnMEP was influenced by BDNF polymorphism and cTBS intensity. Healthy adults can be sorted into subpopulations with distinct cTBS responses that are influenced by genetics.
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影响因子：
--
作者：
Bursac, Zoran;Gauss, C Heath;Williams, David Keith;Hosmer, David W
通讯作者：
Hosmer, David W
最佳数量的脉冲数量作为神经腔内颅磁刺激的结果度量。
DOI：
10.1016/j.clinph.2016.04.001
发表时间：
2016-08
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Chang WH;Fried PJ;Saxena S;Jannati A;Gomes-Osman J;Kim YH;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
8.3
作者：
Ackerley, Suzanne J.;Stinear, Cathy M.;Byblow, Winston D.
通讯作者：
Byblow, Winston D.
影响因子：
3.4
作者：
Cirillo, John;Hughes, James;Semmler, John G.
通讯作者：
Semmler, John G.
影响因子：
5.5
作者：
Cheeran, Binith;Talelli, Penelope;Rothwell, John C.
通讯作者：
Rothwell, John C.