Experimental verification of IMPT treatment plans in an anthropomorphic phantom in the presence of delivery uncertainties
Experimental verification of IMPT treatment plans in an anthropomorphic phantom in the presence of delivery uncertainties
复制标题
在存在交付不确定性的情况下对拟人体模中的 IMPT 治疗计划进行实验验证
DOI：
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发表时间：
2011
影响因子：
3.5
通讯作者：
A. Lomax
中科院分区：
文献类型：
--
作者：
F. Albertini;M. Casiraghi;S. Lorentini;B. Rombi;A. Lomax
在新开发的拟人模型中测量临床相关的调强质子治疗 (IMPT) 治疗计划，(i) 在存在高异质性的情况下评估计划的准确性，(ii) 在治疗不确定性（范围和空间）的情况下测量计划的稳健性。新模型由五种不同的组织替代材料组成，模拟不同的组织类型，并被切割成矢状面，以便于验证共面质子场。 GafChromic 胶片被放置在模型的不同平面上，并且 3D-IMPT 和远端边缘跟踪 (DET) 计划被传送到模拟颅底脊索瘤的体积。此外，还计划对经过 HU 单元修改的体模 CT 进行治疗，以模拟系统范围不确定性（范围误差治疗）。最后，通过旋转模型来模拟空间误差，交付了计划。结果显示，计算的剂量分布和测量的剂量分布之间具有极好的一致性：对于 3D-IMPT 和 DET 计划，伽玛值 <1 (3%/3 mm) 的点分别 >99% 和 98%。对于距离和空间误差，3D-IMPT 计划比 DET 计划更稳健。这两个计划对范围的不确定性比对空间不确定性的稳健性更强。最后，对于范围误差治疗，将测量的分布与治疗计划系统中预测交付误差的模型进行比较。两种 IMPT 计划的模型和测量结果之间存在良好的一致性。
Clinically relevant intensity modulated proton therapy (IMPT) treatment plans were measured in a newly developed anthropomorphic phantom (i) to assess plan accuracy in the presence of high heterogeneity and (ii) to measure plan robustness in the case of treatment uncertainties (range and spatial). The new phantom consists of five different tissue substitute materials simulating different tissue types and was cut into sagittal planes so as to facilitate the verification of co-planar proton fields. GafChromic films were positioned in the different planes of the phantom, and 3D-IMPT and distal edge tracking (DET) plans were delivered to a volume simulating a skull base chordoma. In addition, treatments planned on CTs of the phantom with HU units modified were delivered to simulate systematic range uncertainties (range-error treatments). Finally, plans were delivered with the phantom rotated to simulate spatial errors. Results show excellent agreement between the calculated and the measured dose distribution: >99% and 98% of points with a gamma value <1 (3%/3 mm) for the 3D-IMPT and the DET plan, respectively. For both range and spatial errors, the 3D-IMPT plan was more robust than the DET plan. Both plans were more robust to range than to the spatial uncertainties. Finally, for range error treatments, measured distributions were compared to a model for predicting delivery errors in the treatment planning system. Good agreement has been found between the model and the measurements for both types of IMPT plan.
影响因子：
3.8
作者：
GOITEIN, M
通讯作者：
GOITEIN, M
影响因子：
3.8
作者：
Unkelbach, Jan;Bortfeld, Thomas;Soukup, Martin
通讯作者：
Soukup, Martin