Cellular Aspects of Hormonally Controlled Pigment Translocations Within Chromatophores of Poikilothermic Vertebrates
Cellular Aspects of Hormonally Controlled Pigment Translocations Within Chromatophores of Poikilothermic Vertebrates
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变温脊椎动物色素细胞内激素控制的色素易位的细胞方面
DOI：
10.1093/icb/23.3.559
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发表时间：
1983
影响因子：
2.6
通讯作者：
R. R. Novales
中科院分区：
文献类型：
--
作者：
R. R. Novales
众所周知，脊椎动物促黑素细胞激素 (MSH) 引发的色素运动是由环磷酸腺苷 (cAMP) 在细胞水平上介导的。 cAMP 的类似作用表现在儿茶酚胺通过 rβ3 肾上腺素受体发挥黑素体分散作用。因此，MSH 和 rβ3-肾上腺素能激动剂会导致色素细胞内 cAMP 升高。另一方面，cAMP 水平的降低似乎与褪黑激素和 α-肾上腺素能激动剂的美白作用有关。根据测试的细胞类型和物种，环磷酸鸟苷 (cGMP) 可能没有任何作用或导致皮肤变黑或变白。尽管cGMP会引起青蛙皮肤变白，但由于缺乏生理性变白剂的证据，因此很难确定cGMP的作用。环核苷酸的作用机制和色素移位机制的细节还远不清楚，但最近的研究表明，游离钙离子水平的变化起着关键作用。本文主要从cGMP的美白作用、离子载体A23187的增黑作用、脑啡肽和内啡肽对色素细胞的作用三个方面进行综述。此外，新数据支持这样的概念：A23187 诱导的青蛙皮肤变黑不涉及前列腺素生物合成或腺苷酸环化酶刺激。
Pigment movements triggered by the vertebrate melanocyte-stimulating hormone (MSH) are known to be mediated at the cellular level by cyclic adenosine monophosphate (cAMP). A similar role for cAMP is indicated in the melanosome-dispersing action of catecholamines acting via rβ3-adrenergic receptors. Thus, MSH and rβ3-adrenergic agonists cause an elevation of cAMP within chromatophores. On the other hand, a lowering of cAMP level seems to be associated with the paling action of melatonin and α-adrenergic agonists. Depending upon the cell type and species tested, cyclic guanosme monophosphate (cGMP) may have no effect or cause either darkening or paling. Although cGMP induces paling in frog skin, the lack of evidence for a physiological paling agent makes it difficult to assign a role for cGMP The mechanism of action of cyclic nucleotides and the details of the pigment-translocating mechanism are far from clear, but recent studies indicate that changes in free calcium ion levels play a critical role. This article will primarily review three areas' the paling action of cGMP, the darkening action of ionophore A23187, and the actions of enkephalms and endorphins on chromatophores. In addition, new data are presented to support the concept that the A23187-induced darkening of frog skin does not involve either prostaglandin biosynthesis or adenylate cyclase stimulation.
影响因子：
56.9
作者：
HADLEY, ME;ANDERSON, B;HRUBY, VJ
通讯作者：
HRUBY, VJ