Cytotoxic T Lymphocytes Expressing GPR56 are Up-regulated in the Peripheral Blood of Patients with Active Rheumatoid Arthritis and Reflect Disease Progression
Cytotoxic T Lymphocytes Expressing GPR56 are Up-regulated in the Peripheral Blood of Patients with Active Rheumatoid Arthritis and Reflect Disease Progression
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活动性类风湿关节炎患者外周血中表达 GPR56 的细胞毒性 T 淋巴细胞上调并反映疾病进展
DOI：
10.1080/08820139.2022.2058403
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发表时间：
2022-04
影响因子：
2.8
通讯作者：
Chen Liu
中科院分区：
文献类型：
--
作者：
Xingyue Zeng;Mohan Zheng;Tianci Liu;Ayibaota Bahabayi;Shi Song;Xiayidan Alimu;Rui Kang;Songsong Lu;Ying Song;Chen Liu
**摘要** 目的 本研究旨在阐明类风湿关节炎（RA）患者CD4和CD8 T淋巴细胞中GPR56和（或）颗粒酶B（GZMB）阳性细胞百分比的变化，并探讨其在诊断及反映疾病进展方面的临床价值。
你提供的英文内容最后“reflecting the pro”不完整，推测是“reflecting the progression” ，以上译文按此推测补充完整后翻译。
ABSTRACT Objective This study aims to elucidate the changes in the percentage of GPR56 and/or granzyme B (GZMB) positive cells in rheumatoid arthritis (RA) CD4 and CD8 T lymphocytes, and to explore their clinical value in diagnosing and reflecting the progression of RA. Methods The percentages of GPR56 and/or GZMB positive cells were analyzed in peripheral blood (PB) and spleen T cells in a collagen-induced arthritis (CIA) model established in DBA/1 mice. The percentages of GPR56+ and/or GZMB+ cells were further analyzed in PBs from RA patients and healthy controls. Correlation analysis was performed between clinical indicators and GPR56+, GZMB+, and GPR56+ GZMB+ T cells. Receiver operating characteristic (ROC) curves were used to evaluate the value of GPR56 and GZMB in differentiating active and stable remitting RA. Results GPR56+ levels were increased in CD4 and CD8 T cells in the PB of CIA mice. The percentages of GPR56+ and GZMB+ cells were increased in both CD4 and CD8 T cell subsets in patients with active RA. GPR56+, GZMB+, and GPR56+ GZMB+ cells were positively correlated with rheumatoid factor and DAS28. ROC analysis revealed that AUCs for GPR56+, GZMB+, and GPR56+ GZMB+ cell percentages to distinguish active RA from stable remission RA were 0.7106, 0.6941, 0.7024, with cut-off values of 16.35, 16.40, 14.80 in CD4 + T cells, and 0.8031, 0.8086, 0.8196 with cut-off values 60.25, 62.15, 40.15 in CD8 + T cells, respectively. Conclusions GPR56+ and/or GZMB+ T cells are up-regulated in patients with active RA and reflect their condition. The detection of GPR56 and GZMB is helpful for RA disease assessment.
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影响因子：
32.4
作者：
Sathaliyawala T;Kubota M;Yudanin N;Turner D;Camp P;Thome JJ;Bickham KL;Lerner H;Goldstein M;Sykes M;Kato T;Farber DL
通讯作者：
Farber DL
影响因子：
5.8
作者：
Kumar A;Perdomo MF;Kantele A;Hedman L;Hedman K;Franssila R
通讯作者：
Franssila R
影响因子：
64.8
作者：
McKinney EF;Lee JC;Jayne DR;Lyons PA;Smith KG
通讯作者：
Smith KG
影响因子：
9
作者：
Derksen VFAM;Huizinga TWJ;van der Woude D
通讯作者：
van der Woude D
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
通讯作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker