Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets.
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets.
复制标题
DOI：
10.1016/j.immuni.2012.09.020
复制
发表时间：
2013-01-24
期刊：
影响因子：
32.4
通讯作者：
Farber DL
中科院分区：
文献类型：
--
作者：
Sathaliyawala T;Kubota M;Yudanin N;Turner D;Camp P;Thome JJ;Bickham KL;Lerner H;Goldstein M;Sykes M;Kato T;Farber DL
人类T细胞的知识主要来自外周血的研究，而它们在组织中的分布和功能在很大程度上仍然未知。在这里，我们提出了一个独特的分析人类T细胞的淋巴和粘膜组织从个人器官捐赠者，揭示组织内在的幼稚，效应和记忆亚群之间保存不同的个人。产生IL-2的免疫记忆性CD 4 + T细胞在粘膜组织中占主导地位，并在淋巴组织中积累为中枢记忆性亚群，而CD 8 + T细胞在淋巴组织中维持为幼稚亚群，而产生IFN-γ的效应记忆性CD 8 + T细胞在粘膜部位。T细胞活化标志物CD 69在所有组织中由记忆T细胞组成性表达，将其与循环亚群区分开，粘膜记忆T细胞表现出额外的不同表型和功能特性。我们的研究结果提供了人类T细胞区室化的评估，作为了解人类适应性免疫的新基线。
Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector and memory subsets conserved between diverse individuals. Effector-memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central-memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naïve subsets in lymphoid tissues and IFN-γ-producing effector-memory CD8+ T cells in mucosal sites. The T cell activation marker, CD69, was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
登录
查看更多内容
人T细胞的稳态膨胀和表型转化取决于与APC的外周相互作用。
DOI：
10.4049/jimmunol.0901711
发表时间：
2010-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Onoe T;Kalscheuer H;Chittenden M;Zhao G;Yang YG;Sykes M
通讯作者：
Sykes M
影响因子：
82.9
作者：
Gattinoni L;Lugli E;Ji Y;Pos Z;Paulos CM;Quigley MF;Almeida JR;Gostick E;Yu Z;Carpenito C;Wang E;Douek DC;Price DA;June CH;Marincola FM;Roederer M;Restifo NP
通讯作者：
Restifo NP
影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
4.4
作者：
Masopust, D;Vezys, V;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.4049/jimmunol.1102695
发表时间：
2012-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Masopust D;Picker LJ
通讯作者：
Picker LJ