Quantitative shear wave ultrasound elastography: initial experience in solid breast masses.
Quantitative shear wave ultrasound elastography: initial experience in solid breast masses.
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DOI：
10.1186/bcr2787
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Thompson A
中科院分区：
文献类型：
--
作者：
Evans A;Whelehan P;Thomson K;McLean D;Brauer K;Purdie C;Jordan L;Baker L;Thompson A
剪切波弹性成像是一种在乳腺超声检查中获得定量组织弹性数据的新方法。本研究的目的是（1）确定剪切波弹性成像的可重复性（2）将一系列实性乳腺肿块的弹性值与组织学检查结果相关联，（3）比较剪切波弹性成像与灰阶超声对良/恶性的分类。使用Aixplorer®超声系统（SuperSonic Imagine，Aix en Provence，France），在52名连续患者中识别出53处实体乳腺病变。每个病变获得两个正交弹性成像图像。观察者记录两张弹性成像图像上最硬区域上方的感兴趣区域（ROI）的平均弹性值，并计算每个病变的平均值。15名患者的子集有两个弹性成像图像由额外的操作员获得。在（1）两名观察员分析同一对图像和（2）两名不同操作员拍摄的同一病变的两对图像的结果之间评估观察结果的再现性。所有病变均经皮穿刺活检。弹性成像测量与组织学结果相关。在10例患者的初步经验后，选择50千帕（kPa）的平均弹性截止值用于良性/恶性分化。根据美国放射学会（ACR）乳腺成像报告和数据系统（BI-RADS）对灰度图像进行分类。BI-RADS分类1-3被视为良性，而BI-RADS分类4和5被归类为恶性。组织学诊断为良性病变23例，恶性病变30例。测量平均弹性产生的组内相关系数为0.99的两个观察员评估相同的对弹性成像图像。由两个独立的运营商所采取的图像分析得到了0.80的组内相关系数。剪切波弹性成像与灰阶BI-RADS的性能图分别为敏感性：97% vs 87%，特异性：83% vs 78%，阳性预测值（PPV）：88% vs 84%，阴性预测值（NPV）：95% vs 82%，准确性：91% vs 83%。这些差异不具有统计学显著性。剪切波弹性成像提供了定量和可重复的信息，对乳腺实性病变的诊断准确性至少与灰度超声BI-RADS分类一样好。
Shear wave elastography is a new method of obtaining quantitative tissue elasticity data during breast ultrasound examinations. The aims of this study were (1) to determine the reproducibility of shear wave elastography (2) to correlate the elasticity values of a series of solid breast masses with histological findings and (3) to compare shear wave elastography with greyscale ultrasound for benign/malignant classification. Using the Aixplorer® ultrasound system (SuperSonic Imagine, Aix en Provence, France), 53 solid breast lesions were identified in 52 consecutive patients. Two orthogonal elastography images were obtained of each lesion. Observers noted the mean elasticity values in regions of interest (ROI) placed over the stiffest areas on the two elastography images and a mean value was calculated for each lesion. A sub-set of 15 patients had two elastography images obtained by an additional operator. Reproducibility of observations was assessed between (1) two observers analysing the same pair of images and (2) findings from two pairs of images of the same lesion taken by two different operators. All lesions were subjected to percutaneous biopsy. Elastography measurements were correlated with histology results. After preliminary experience with 10 patients a mean elasticity cut off value of 50 kilopascals (kPa) was selected for benign/malignant differentiation. Greyscale images were classified according to the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS). BI-RADS categories 1-3 were taken as benign while BI-RADS categories 4 and 5 were classified as malignant. Twenty-three benign lesions and 30 cancers were diagnosed on histology. Measurement of mean elasticity yielded an intraclass correlation coefficient of 0.99 for two observers assessing the same pairs of elastography images. Analysis of images taken by two independent operators gave an intraclass correlation coefficient of 0.80. Shear wave elastography versus greyscale BI-RADS performance figures were sensitivity: 97% vs 87%, specificity: 83% vs 78%, positive predictive value (PPV): 88% vs 84%, negative predictive value (NPV): 95% vs 82% and accuracy: 91% vs 83% respectively. These differences were not statistically significant. Shear wave elastography gives quantitative and reproducible information on solid breast lesions with diagnostic accuracy at least as good as greyscale ultrasound with BI-RADS classification.
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影响因子：
19.7
作者：
Athanasiou, Alexandra;Tardivon, Anne;Neuenschwander, Sylvia
通讯作者：
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影响因子：
19.7
作者：
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通讯作者：
Hangiandreou, Nicholas J.