Hypertensive heart disease: risk factors, complications and mechanisms.

Hypertensive heart disease: risk factors, complications and mechanisms.
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DOI:
10.3389/fcvm.2023.1205475
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发表时间:
2023
影响因子:
3.6
通讯作者:
Kirabo, Annet
Kirabo, Annet
中科院分区:
医学3区
文献类型:
--
作者:
Masenga, Sepiso K.;Kirabo, Annet

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高血压性心脏病构成了功能和结构功能障碍,以及由于慢性不受控制的高血压而主要发生在左心室、左心房和冠状动脉中的发病机制。高血压性心脏病的报道不足,其相关因素和并发症的机制也没有得到很好的阐述。本文就高血压性心脏病的研究现状作一综述,并对高血压性心脏病的发生、发展及并发症,特别是左室肥厚、心房颤动、心力衰竭和冠状动脉病变的发生机制作一详细讨论。我们还简要强调了饮食中的盐,免疫和遗传易感性在高血压心脏病发病机制中的作用。
Hypertensive heart disease constitutes functional and structural dysfunction and pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries due to chronic uncontrolled hypertension. Hypertensive heart disease is underreported and the mechanisms underlying its correlates and complications are not well elaborated. In this review, we summarize the current understanding of hypertensive heart disease, we discuss in detail the mechanisms associated with development and complications of hypertensive heart disease especially left ventricular hypertrophy, atrial fibrillation, heart failure and coronary artery disease. We also briefly highlight the role of dietary salt, immunity and genetic predisposition in hypertensive heart disease pathogenesis.
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