Variation in innate immunity genes and risk of multiple myeloma.
Variation in innate immunity genes and risk of multiple myeloma.
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DOI：
10.1002/hon.954
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发表时间：
2011-03
影响因子：
3.3
通讯作者：
Baris, Dalsu
中科院分区：
文献类型：
--
作者：
Purdue, Mark P.;Lan, Qing;Menashe, Idan;Zheng, Tongzhang;Zhang, Yawei;Yeager, Meredith;Hosgood, H. Dean, III;Zahm, Shelia H.;Chanock, Stephen J.;Rothman, Nathaniel;Baris, Dalsu
多发性骨髓瘤（MM）是一种B细胞淋巴系统恶性肿瘤，怀疑与免疫因素有关。鉴于最近的研究结果与非霍奇金淋巴瘤的先天免疫基因的单核苷酸多态性（SNP），我们进行了先天免疫基因变异的调查，使用标本从人口为基础的病例对照研究的MM在康涅狄格州的妇女。在非西班牙裔高加索受试者（103例，475例对照）中对总结149个基因区域中常见变异的标签SNP（N= 1，461）进行基因分型。采用非条件Logistic回归计算SNP与MM相关性的比值比（OR）和95%置信区间（CI），同时采用MinP检验在基因水平上研究与MM的相关性。我们计算了排列调整的P值和错误发现率（FDR），以分别解释SNP水平和基因水平测试中进行的比较次数。当控制FDR ≤10%时，三个基因与MM相关：SERPINE 1（PMinP<0.0001; FDR=0.02）、HGF（PMinP=0.0006; FDR=0.06）和CCR 7（PMinP=0.001; FDR=0.08）。两个SNP表现出强相关性：SERPINE 1 rs 2227667（P=2.1×10−5，Ppermutation=0.03）和HGF rs 17501108（P=5.0×10−5，Ppermutation=0.07）。我们的研究结果表明，SERPINE 1和HGF的遗传变异，可能还有CCR 7，与MM风险相关，需要在其他研究中进一步调查。
Multiple myeloma (MM) is a B-cell lymphoid malignancy suspected to be associated with immunologic factors. Given recent findings associating single-nucleotide polymorphisms (SNPs) in innate immunity genes with non-Hodgkin lymphoma, we conducted an investigation of innate immune gene variants using specimens from a population-based case-control study of MM conducted in Connecticut women. Tag SNPs (N=1,461) summarizing common variation in 149 gene regions were genotyped in non-Hispanic Caucasian subjects (103 cases, 475 controls). Odds ratios (OR) and 95% confidence intervals (CI) relating SNP associations with MM were computed using unconditional logistic regression, while the MinP test was used to investigate associations with MM at the gene level. We calculated permutation-adjusted P-values and false discovery rates (FDR) to account for the number of comparisons performed in SNP-level and gene-level tests, respectively. Three genes were associated with MM when controlling for a FDR of ≤10%: SERPINE1 (PMinP<0.0001; FDR=0.02), HGF (PMinP=0.0006; FDR=0.06) and CCR7 (PMinP=0.001; FDR=0.08). Two SNPs demonstrated robust associations: SERPINE1 rs2227667 (P=2.1×10−5, Ppermutation=0.03) and HGF rs17501108 (P=5.0×10−5, Ppermutation=0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies.
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影响因子：
6.4
作者：
Landgren, O;Linet, MS;Goldin, LR
通讯作者：
Goldin, LR
影响因子：
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作者：
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影响因子：
11.4
作者：
Derksen, PWB;de Gorter, DJJ;Pals, ST
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影响因子：
15.3
作者：
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通讯作者：
Caux, C
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y