In vivo whole animal fluorescence imaging of a microparticle-based oral vaccine containing (CuInSe(x)S(2-x))/ZnS core/shell quantum dots.

In vivo whole animal fluorescence imaging of a microparticle-based oral vaccine containing (CuInSe(x)S(2-x))/ZnS core/shell quantum dots.
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DOI:
10.1021/nl402054w
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发表时间:
2013-09-11
期刊:
影响因子:
10.8
通讯作者:
Korgel BA
Korgel BA
中科院分区:
材料科学1区
文献类型:
--
作者:
Panthani MG;Khan TA;Reid DK;Hellebusch DJ;Rasch MR;Maynard JA;Korgel BA

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Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.
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