Lesion of the rostromedial tegmental nucleus increases voluntary ethanol consumption and accelerates extinction of ethanol-induced conditioned taste aversion.
Lesion of the rostromedial tegmental nucleus increases voluntary ethanol consumption and accelerates extinction of ethanol-induced conditioned taste aversion.
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结胶换膜核的病变增加了自愿的乙醇消耗，并加速了乙醇诱导的条件味觉厌恶的灭绝。
DOI：
10.1007/s00213-016-4406-7
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发表时间：
2016-10
影响因子：
3.4
通讯作者：
Taha, Sharif A.
中科院分区：
文献类型：
--
作者：
Sheth, Chandni;Furlong, Teri M.;Keefe, Kristen A.;Taha, Sharif A.
乙醇具有奖励和厌恶属性，这些属性的平衡影响自愿乙醇消费。临床前和临床证据表明，乙醇的厌恶特性限制了摄入量。乙醇引起的厌恶学习的神经回路尚未完全了解。我们以前已经表明，外侧缰（LHb），厌恶条件反射的关键区域，在乙醇导向的行为中起着重要的作用。然而，LHb发挥其作用的神经回路是未知的。在本研究中，我们调查的作用，头内侧被盖核（RMTg），一个主要的LHb投射目标，在调节乙醇导向的行为。大鼠接受假手术或RMTg病变，并在自愿乙醇消费过程中进行了研究;操作性乙醇自我管理，灭绝，育亨宾诱导恢复乙醇寻求;和乙醇诱导的条件性味觉厌恶（CTA）。RMTg病变增加了自愿乙醇消耗量，加速了乙醇诱导的CTA消退。RMTg在调节自愿乙醇消费中起着重要作用，可能通过介导乙醇诱导的厌恶性条件反射。
Ethanol has rewarding and aversive properties, and the balance of these properties influences voluntary ethanol consumption. Preclinical and clinical evidence show that the aversive properties of ethanol limit intake. The neural circuits underlying ethanol-induced aversion learning are not fully understood. We have previously shown that the lateral habenula (LHb), a region critical for aversive conditioning, plays an important role in ethanol-directed behaviors. However, the neurocircuitry through which LHb exerts its actions is unknown. In the present study, we investigate a role for the rostromedial tegmental nucleus (RMTg), a major LHb projection target, in regulating ethanol-directed behaviors. Rats received either sham or RMTg lesions and were studied during voluntary ethanol consumption; operant ethanol self-administration, extinction, and yohimbine-induced reinstatement of ethanol-seeking; and ethanol-induced conditioned taste aversion (CTA). RMTg lesions increased voluntary ethanol consumption and accelerated extinction of ethanol-induced CTA. The RMTg plays an important role in regulating voluntary ethanol consumption, possibly by mediating ethanol-induced aversive conditioning.
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影响因子：
3.7
作者：
Haack AK;Sheth C;Schwager AL;Sinclair MS;Tandon S;Taha SA
通讯作者：
Taha SA
影响因子：
2.7
作者：
Bertholomey, Megan L.;Verplaetse, Terril L.;Czachowski, Cristine L.
通讯作者：
Czachowski, Cristine L.
影响因子：
2.3
作者：
Czachowski, CL;Santini, LA;Samson, HH
通讯作者：
Samson, HH
影响因子：
5.3
作者：
Ji, Huifang;Shepard, Paul D.
通讯作者：
Shepard, Paul D.
影响因子：
2.3
作者：
Camicella, Sebastien;Amamoto, Ryoji;Ron, Dorit
通讯作者：
Ron, Dorit