Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats.
Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats.
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DOI：
10.1016/j.bbr.2012.10.030
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发表时间：
2013-02-01
影响因子：
2.7
通讯作者：
Czachowski, Cristine L.
中科院分区：
文献类型：
--
作者：
Bertholomey, Megan L.;Verplaetse, Terril L.;Czachowski, Cristine L.
有证据表明，压力会增加饮酒，并促进人类的复发。评估相关行为的动物模型包括吸管乙醇自我给药和应激诱导的恢复范例。虽然选择性繁殖相同的高酒精饮用行为，酒精偏好P大鼠似乎表现出更大的敏感性，乙醇强化比高酒精饮用HAD大鼠。本实验测试了药理学应激源育亨宾对寻求和消耗乙醇的动机的影响，使用雄性P和HAD-2大鼠实施组合吸管/恢复模型。在使用吸管程序自我施用乙醇的训练之后，测试大鼠对乙醇饮用的育亨宾（0.625-2.5 mg/kg）的影响。随后，测试1.25 mg/kg育亨宾对乙醇寻求恢复的影响。育亨宾（0.625和1.25 mg/kg）增加乙醇自我给药，后者剂量也减少了潜伏期，以完成反应要求。育亨宾引起恢复乙醇寻求在这两条线。HAD-2大鼠饮用更多的乙醇，但表现出类似的反应，乙醇相关的杠杆相比，P大鼠。这些发现扩展了恢复和吸管模型，并证明了进一步探索这种独特的组合范式。尽管先前的证据表明，P大鼠更积极地寻求和消费乙醇，P和HAD-2大鼠之间的这些行为的差异是不系统的，在本实验中。进一步的研究可能会阐明，无论是选择线可能比其他选择性繁殖或远系繁殖的大鼠更敏感的压力相关的变化，乙醇的增强效果。
Evidence suggests that stress increases alcohol drinking and promotes relapse in humans. Animal models that assess related behaviors include the sipper tube ethanol self-administration and the stress-induced reinstatement paradigms. While selectively bred for the same high-ethanol-drinking behavior, alcohol-preferring P rats appear to show greater sensitivity to ethanol reinforcement than high-alcohol-drinking HAD rats. The present experiment tested the effects of the pharmacological stressor, yohimbine, on the motivation to seek and consume ethanol implementing a combined sipper tube/reinstatement model using male P and HAD-2 rats. Following training to self-administer ethanol using the sipper tube procedure, rats were tested for the effects of yohimbine (0.625-2.5 mg/kg) on ethanol drinking. Subsequently, rats were tested for the effects of 1.25 mg/kg yohimbine on reinstatement of ethanol seeking. Yohimbine (0.625 and 1.25 mg/kg) increased ethanol self-administration, and the latter dose also decreased latency to complete the response requirement. Yohimbine elicited reinstatement of ethanol seeking in both lines. HAD-2 rats drank more ethanol, but showed similar responding on the ethanol-associated lever compared to P rats. These findings extend both the reinstatement and sipper tube models and justify further exploration of this unique combined paradigm. Despite prior evidence suggesting that P rats are more motivated to seek and consume ethanol, differences in these behaviors between P and HAD-2 rats were not systematic in the present experiment. Further investigation may elucidate whether either selected line may be more sensitive than other selectively bred or outbred rats to stress-related changes in ethanol's reinforcing effects.
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影响因子：
4
作者：
Grzywacz, Joseph G;Almeida, David M
通讯作者：
Almeida, David M
影响因子：
3.3
作者：
Funk, D;Li, Z;Lê, AD
通讯作者：
Lê, AD
DOI：
10.1111/j.1530-0277.2003.tb04413.x
发表时间：
2003-06-01
影响因子：
3.2
作者：
Badia-Elder, NE;Stewart, RB;Li, TK
通讯作者：
Li, TK
影响因子：
11.3
作者：
CHARNEY, DS;WOODS, SW;HENINGER, GR
通讯作者：
HENINGER, GR
DOI：
10.1097/01.alc.0000036284.74513.a5
发表时间：
2002-11-01
影响因子：
3.2
作者：
Czachowski, CL;Samson, HH
通讯作者：
Samson, HH