Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
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DOI：
10.1016/j.neuroimage.2008.10.043
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发表时间：
2009-03
期刊：
影响因子：
5.7
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Morra JH;Tu Z;Apostolova LG;Green AE;Avedissian C;Madsen SK;Parikshak N;Toga AW;Jack CR Jr;Schuff N;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
海马体是阿尔茨海默病 (AD) 中最早退化的结构之一，是许多影响老年人大脑退化率因素研究的目标。在迄今为止最大规模的脑图谱研究之一中，我们对 490 名受试者的海马变性随时间变化的 3D 轮廓进行了绘制，这些受试者在 1 年的时间间隔内使用脑部 MRI 扫描了两次（980 次扫描）。我们检查了 97 名 AD 受试者（49 名男性/48 名女性）、148 名健康对照受试者（75 名男性/73 名女性）和 245 名轻度认知障碍受试者（MCI；160 名男性/85 名女性）的基线和 1 年随访扫描。我们使用之前经过验证的基于 AdaBoost 的自动分割方法，在所有 980 次扫描中创建 3D 海马表面模型。海马体积损失率随着诊断的恶化而增加（正常=0.66%/年；MCI=3.12%/年；AD=5.59%/年），并且与简易精神状态检查（MMSE）分数以及总体和总和临床痴呆评定量表（CDR）分数的基线和间隔变化相关。基于表面的统计图可视化了所有三个诊断组中持续萎缩的选择性概况。携带 ApoE4 基因的健康对照比非携带者萎缩得更快，而受过教育的对照则萎缩得更慢；从 MCI 到 AD 的转化者比非转化者表现出更快的萎缩。海马体损失率可以快速绘制出来，并且它们可以密切跟踪认知能力的下降，可以在药物试验中用作阿尔茨海默病的替代标志物。他们还揭示了认知完整的受试者在遗传上有更严重的萎缩。
As one of the earliest structures to degenerate in Alzheimer’s disease (AD), the hippocampus is the target of many studies of factors that influence rates of brain degeneration in the elderly. In one of the largest brain mapping studies to date, we mapped the 3D profile of hippocampal degeneration over time in 490 subjects scanned twice with brain MRI over a 1-year interval (980 scans). We examined baseline and 1-year follow-up scans of 97 AD subjects (49 males/48 females), 148 healthy control subjects (75 males/73 females), and 245 subjects with mild cognitive impairment (MCI; 160 males/85 females). We used our previously validated automated segmentation method, based on AdaBoost, to create 3D hippocampal surface models in all 980 scans. Hippocampal volume loss rates increased with worsening diagnosis (normal=0.66%/year; MCI=3.12%/year; AD=5.59%/year), and correlated with both baseline and interval changes in Mini-Mental State Examination (MMSE) scores and global and sum-of-boxes Clinical Dementia Rating scale (CDR) scores. Surface-based statistical maps visualized a selective profile of ongoing atrophy in all three diagnostic groups. Healthy controls carrying the ApoE4 gene atrophied faster than non-carriers, while more educated controls atrophied more slowly; converters from MCI to AD showed faster atrophy than non-converters. Hippocampal loss rates can be rapidly mapped, and they track cognitive decline closely enough to be used as surrogate markers of Alzheimer’s disease in drug trials. They also reveal genetically greater atrophy in cognitively intact subjects.
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