A revised nomenclature for the lemur family of protein kinases.
A revised nomenclature for the lemur family of protein kinases.
复制标题
DOI：
10.1038/s42003-023-05671-8
复制
发表时间：
2024-01-08
影响因子：
5.9
通讯作者：
Giamas, Georgios
中科院分区：
文献类型：
--
作者：
Morotz, Gabor M.;Bradbury, Neil A.;Caluseriu, Oana;Hisanaga, Shin-ichi;Miller, Christopher C. J.;Swiatecka-Urban, Agnieszka;Lenz, Heinz-Josef;Moss, Stephen J.;Giamas, Georgios
近年来，狐猴蛋白激酶家族受到人们的广泛关注，因为它们参与了多种细胞过程，包括轴突运输和内体运输的调节，突触功能的调节，记忆和学习，它们位于几个细胞内信号通路的中央。大量研究还表明，狐猴蛋白激酶在多种癌症、囊性纤维化和神经退行性疾病的发生和发展中起着重要作用。然而，平行的发现和对其激酶活性的不准确预测导致了对这些蛋白质的命名混乱和误导。在这里，一组在狐猴蛋白激酶家族方面拥有专业知识的国际科学家提出了一种新的命名法来纠正这个问题，并通过提供关于这些分子的一致信息来最终帮助科学界。在这里，一组对狐猴蛋白激酶家族有专长的科学家提出了一种新的狐猴蛋白激酶命名法。
The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including regulation of axonal transport and endosomal trafficking, modulation of synaptic functions, memory and learning, and they are centrally placed in several intracellular signalling pathways. Numerous studies have also implicated role of the lemur kinases in the development and progression of a wide range of cancers, cystic fibrosis, and neurodegenerative diseases. However, parallel discoveries and inaccurate prediction of their kinase activity have resulted in a confusing and misleading nomenclature of these proteins. Herein, a group of international scientists with expertise in lemur family of protein kinases set forth a novel nomenclature to rectify this problem and ultimately help the scientific community by providing consistent information about these molecules. Here a group of scientists with expertise in lemur family of protein kinases propose a new nomenclature for lemur kinases.
登录
查看更多内容
影响因子：
14.3
作者：
Du, Mulong;Gu, Dongying;Xin, Junyi;Peters, Ulrike;Song, Mingyang;Cai, Guoshuai;Li, Shuwei;Ben, Shuai;Meng, Yixuan;Chu, Haiyan;Chen, Lianmin;Wang, Qianghu;Zhu, Lingjun;Fu, Zan;Zhang, Zhengdon;Wang, Meilin
通讯作者：
Wang, Meilin
影响因子：
3.6
作者：
Bencze J;Mórotz GM;Seo W;Bencs V;Kálmán J;Miller CCJ;Hortobágyi T
通讯作者：
Hortobágyi T
影响因子：
4.7
作者：
Cruz DF;Mitash N;Mu F;Farinha CM;Swiatecka-Urban A
通讯作者：
Swiatecka-Urban A
影响因子：
4.6
作者：
Bencze, Janos;Szarka, Mate;Hortobagyi, Tibor
通讯作者：
Hortobagyi, Tibor
影响因子：
8
作者：
Gaozza, E;Baker, SJ;Reddy, EP
通讯作者：
Reddy, EP