Sperm parameters and anti-Müllerian hormone remain stable with Helicobacter pylori infection: a cross-sectional study.
Sperm parameters and anti-Müllerian hormone remain stable with Helicobacter pylori infection: a cross-sectional study.
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幽门螺杆菌感染时精子参数和抗苗勒氏管激素保持稳定：一项横断面研究。
DOI：
10.1186/s12894-020-00725-z
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发表时间：
2020-11-26
期刊：
影响因子：
2
通讯作者：
Jin M
中科院分区：
文献类型：
--
作者：
Feng C;Lv PP;Huang CC;Yang SQ;Yao QP;Shen JM;Jin M
背景和目的幽门螺杆菌（Helicobacter pylori，HP）感染在不孕人群中的发生率较高。HP感染可导致精子参数下降，治疗HP感染可提高精子质量。然而，研究不孕症和HP感染之间的关系仍然有限，需要更多的证据。因此，我们进行了本研究，以探讨HP感染对男性精子质量和对女性卵巢储备的影响。方法共有16,522例患者，他们于2016年1月至2019年6月因腹部不适就诊于浙江大学第二医院，并接受了13/14 C-尿素呼气HP试验。其中，565人在过去三个月内进行了精子分析或卵巢储备测试，并参与进一步分析。采用电化学发光法检测血清抗苗勒管激素（AMH）和性激素水平。结果在363例接受精子检查的患者中，136例（37.47%）有HP感染。在202例AMH试验患者中，HP感染55例（27.23%）。HP+和HP−组之间的精子浓度和活力无差异（P 0.05）。进一步分层至5岁年龄组的亚组分析证实，精子参数无显著差异（P 0.05）。当与先前发表的数据合并时，未发现精子浓度或活力的显著差异（P 0.05）。同时，本研究发现HP+和HP−组之间血清AMH水平相似（P 0.05）。进一步的亚组分析证实血清AMH水平无显著性差异（P0.05）。
Background and aimsIt has been reported thatHelicobacter pylori(HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females.MethodsA total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a13/14C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method.ResultsAmong 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP− groups (P 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP− groups (P 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P 0.05).ConclusionsThere were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.
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影响因子：
2.1
作者：
Moretti, Elena;Figura, Natale;Collodel, Giulia
通讯作者：
Collodel, Giulia
影响因子：
1.3
作者：
Calzada, Mireya;Lopez, Natividad;Torres, Alberto M.
通讯作者：
Torres, Alberto M.
DOI：
10.2147/ijwh.s24424
发表时间：
2011
期刊：
International journal of women's health
影响因子：
--
作者：
Hajishafiha M;Ghasemi-Rad M;Memari A;Naji S;Mladkova N;Saeedi V
通讯作者：
Saeedi V
影响因子：
4.2
作者：
Park JY;Forman D;Waskito LA;Yamaoka Y;Crabtree JE
通讯作者：
Crabtree JE
影响因子：
4.3
作者：
Ferwana, Mazen;Abdulmajeed, Imad;Knawy, Bandar
通讯作者：
Knawy, Bandar