Immune‐mediated damage is not essential for the expulsion of Nippostrongylus brasiliensis adult worms from the small intestine of mice
Immune‐mediated damage is not essential for the expulsion of Nippostrongylus brasiliensis adult worms from the small intestine of mice
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免疫介导的损伤对于将巴西圆线虫成虫从小鼠小肠中排出并不重要
DOI：
10.1046/j.1365-3024.2002.00472.x
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发表时间：
2002
影响因子：
2.2
通讯作者：
Y. Nawa
中科院分区：
文献类型：
--
作者：
K. Ishiwata;H. Nakao;F. Nakamura‐Uchiyama;Y. Nawa
巴西日本圆线虫蠕虫在初次感染过程中通过两个步骤从大鼠小肠排出。首先，宿主的免疫反应导致蠕虫受损，然后非特异性炎症反应启动驱逐。我们已经在感染N.巴西的。在C57 BL/6小鼠中初次感染后，蠕虫在感染后第5天（p.i.）并且在感染后第9-10天左右被排出。根据大鼠系统，分别假设5天和8天大的蠕虫为“正常”和“受损”。当将从C57 BL/6小鼠获得的5天和8天大的蠕虫通过手术转移到初始C57 BL/6小鼠的小肠中时，5天和8天大的蠕虫在蠕虫植入后第6天（p.w.i.）几乎同时排出。相比之下，当将小鼠来源的5天和8天大的蠕虫植入未处理的Wistar大鼠中时，在p.w.i.第5天排出8天大的蠕虫，而5天大的蠕虫在p.w.i.第8天排出。当使用BALB/c小鼠时获得类似的结果。因此，小鼠可以排出N。巴西蠕虫成虫排出“受损”蠕虫的速度与大鼠一样快，而不管蠕虫的状态（“正常”或“受损”）。Stat 6缺陷型小鼠在p.w.i.第10天不能排出植入的5日龄蠕虫，这表明依赖于Stat 6信号系统的细胞机制对于排出是必要的。当N.将初次感染后5天和15天从Stat 6缺陷小鼠获得的巴西丝虫成虫植入Wistar大鼠，前者在受体大鼠中建立约1周，然后在p.w.i.第10天排出，而后者在产后第4天被驱逐这些结果表明，免疫介导的N.巴西蠕虫成虫（第一步）并不是从小鼠小肠排出的先决条件，尽管成虫实际上会被Stat 6独立的免疫机制损坏。
Nippostrongylus brasiliensis adult worms are expelled from the rat small intestine during a primary infection by two steps. First, host immune responses cause damage to the worms, and then a nonspecific inflammatory response initiates expulsion. We have tested the two‐step expulsion hypothesis in mice infected with N. brasiliensis. After a primary infection in C57BL/6 mice, adult worms started to lay eggs on day 5 postinfection (p.i.) and were expelled around day 9–10 p.i. According to the rat system, 5 day‐ and 8‐day‐old worms were assumed to be ‘normal’ and ‘damaged’, respectively. When 5 day‐ and 8 day‐old worms obtained from C57BL/6 mice were transferred surgically into the small intestine of naive C57BL/6 mice, both 5 day‐ and 8 day‐old worms were almost simultaneously expelled by day 6 postworm implantation (p.w.i.). In contrast, when 5 day‐ and 8 day‐old worms of mouse origin were implanted into naive Wistar rats, 8 day‐old worms were expelled by day 5 p.w.i., while 5 day‐old worms were expelled by day 8 p.w.i. Similar results were obtained when BALB/c mice were used. Therefore, mice can expel N. brasiliensis adult worms as rapidly as rats expel ‘damaged’ worms, regardless of the status of the worms (‘normal’ or ‘damaged’). Stat6‐deficient mice were unable to expel implanted 5 day‐old worms up to day 10 p.w.i., suggesting that cellular mechanisms depending on Stat6‐signalling system are necessary for the expulsion. When N. brasiliensis adult worms obtained from Stat6‐deficient mice 5 and 15 days after a primary infection were implanted into Wistar rats, the former established in the recipient rats for approximately 1 week and were then expelled by day 10 p.w.i., whereas the latter were expelled by day 4 p.w.i. These results suggest that immune‐mediated damage of N. brasiliensis adult worms (first step) is not a prerequisite for expulsion from the small intestine of mice, although adult worms are actually damaged by Stat6‐independent immune mechanisms.
影响因子：
32.4
作者：
Urban, JF;Noben-Trauth, N;Finkelman, FD
通讯作者：
Finkelman, FD
IFN 抑制感染线虫寄生虫巴西圆线虫的小鼠的炎症反应和保护性免疫。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
UrbanJr,JF;Madden,KB;Cheever,AW;Trotta,PP;Katona,IM;Finkelman,FD
通讯作者：
Finkelman,FD
L3T4 和 Lyt-2 T 细胞在 IgE 反应和对巴西圆线虫免疫中的作用。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Katona,IM;UrbanJr,JF;Finkelman,FD
通讯作者：
Finkelman,FD