Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning.
Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning.
复制标题
气味辨别学习期间嗅球颗粒细胞中气味反应的改进分离
DOI：
10.3389/fncel.2020.579349
复制
发表时间：
2020
影响因子：
5.3
通讯作者：
Li A
中科院分区：
文献类型：
--
作者：
Wang D;Chen Y;Chen Y;Li X;Liu P;Yin Z;Li A
在嗅球中，嗅觉信息通过僧帽细胞/簇状细胞转化为整体表征，并且这些表征以依赖于上下文的方式动态变化。特别是，在二尖瓣/簇状细胞的气味表征显示模式分离气味辨别学习。虽然颗粒细胞提供了主要的抑制性输入的二尖瓣/簇状细胞，并在模式分离和嗅觉学习中发挥了重要作用，在气味辨别学习过程中颗粒细胞的气味反应的动力学仍然在很大程度上未知。在这里，我们研究了清醒行为小鼠嗅球颗粒细胞的气味反应，使用纤维光度记录。我们发现，气味引起可靠的，兴奋性反应的颗粒细胞群。有趣的是，在气味辨别学习过程中，颗粒细胞的气味反应表现出改善的分离，并包含有关气味值的信息。总之，我们发现，颗粒细胞在嗅球显示学习相关的可塑性，这表明它们可能介导的模式分离二尖瓣/簇状细胞。
In the olfactory bulb, olfactory information is translated into ensemble representations by mitral/tufted cells, and these representations change dynamically in a context-dependent manner. In particular, odor representations in mitral/tufted cells display pattern separation during odor discrimination learning. Although granule cells provide major inhibitory input to mitral/tufted cells and play an important role in pattern separation and olfactory learning, the dynamics of odor responses in granule cells during odor discrimination learning remain largely unknown. Here, we studied odor responses in granule cells of the olfactory bulb using fiber photometry recordings in awake behaving mice. We found that odors evoked reliable, excitatory responses in the granule cell population. Intriguingly, during odor discrimination learning, odor responses in granule cells exhibited improved separation and contained information about odor value. In conclusion, we show that granule cells in the olfactory bulb display learning-related plasticity, suggesting that they may mediate pattern separation in mitral/tufted cells.
登录
查看更多内容
影响因子：
3.4
作者：
Escanilla, Olga;Arrellanos, Adolfo;Linster, Christiane
通讯作者：
Linster, Christiane
影响因子：
16.6
作者：
Gödde K;Gschwend O;Puchkov D;Pfeffer CK;Carleton A;Jentsch TJ
通讯作者：
Jentsch TJ
影响因子：
5.3
作者：
Andermann ML;Kerlin AM;Reid RC
通讯作者：
Reid RC
影响因子：
16.2
作者：
Abraham NM;Egger V;Shimshek DR;Renden R;Fukunaga I;Sprengel R;Seeburg PH;Klugmann M;Margrie TW;Schaefer AT;Kuner T
通讯作者：
Kuner T
影响因子：
5.3
作者：
Cauthron, Joy L.;Stripling, Jeffrey S.
通讯作者：
Stripling, Jeffrey S.