Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders.
Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders.
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DOI：
10.1016/j.jpsychires.2018.04.006
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发表时间：
2018-07
影响因子：
4.8
通讯作者：
Perez DL
中科院分区：
文献类型：
--
作者：
Williams B;Jalilianhasanpour R;Matin N;Fricchione GL;Sepulcre J;Keshavan MS;LaFrance WC Jr;Dickerson BC;Perez DL
不安全的依恋和适应不良的应对方式是功能性神经障碍（FND）/转换障碍的重要易感因素，但之前没有结构神经影像学研究调查过 FND 人群中与这些危险因素相关的生物标志物。这项磁共振成像研究检查了 FND 患者的皮质厚度和皮质下体积与自我报告的依恋和应对方式相关。我们假设不安全的依恋和适应不良的应对方式与边缘-副边缘结构的改变有关。 FreeSurfer 对 26 名运动 FND 患者（21 名女性；5 名男性）和 27 名健康对照者（22 名女性；5 名男性）进行了皮质厚度和皮质下体积分析。为了进行组间比较，FND 患者根据关系量表问卷、应对方式量表修订版和康纳戴维森弹性量表评分进行分层。还对 FND 患者进行了组内分析。所有分析均在完整队列中进行，并在女性中单独进行，仅评估性别特异性效应。皮质厚度分析在聚类水平上进行了全脑校正；皮质下分析经过 Bonferroni 校正。在患有 FND 的女性中，消除依恋与左侧海马旁皮质厚度的减少相关。对抗性应对与右侧海马体积减小相关，而接受责任与右侧中央前回皮质厚度呈正相关。这些发现对抗抑郁药物的使用进行了调整。与健康女性相比，所有 FND 相关发现均在正常范围内。这些观察结果将边缘-副边缘和运动前结构的个体差异与 FND 的依恋和应对方式联系起来。海马旁厚度与排斥依恋之间的关系可能表明患有 FND 的女性存在异常的社会情感和情境评估。
Insecure attachment and maladaptive coping are important predisposing vulnerabilities for Functional Neurological Disorders (FND)/Conversion Disorder, yet no prior structural neuroimaging studies have investigated biomarkers associated with these risk factors in FND populations. This magnetic resonance imaging study examined cortical thickness and subcortical volumes associated with self-reported attachment and coping styles in patients with FND. We hypothesized that insecure attachment and maladaptive coping would relate to limbic-paralimbic structural alterations. FreeSurfer cortical thickness and subcortical volumetric analyses were performed in 26 patients with motor FND (21 women; 5 men) and 27 healthy controls (22 women; 5 men). For between-group comparisons, patients with FND were stratified by Relationship Scales Questionnaire, Ways of Coping Scale-Revised, and Connor-Davidson Resilience Scale scores. Within-group analyses were also performed in patients with FND. All analyses were performed in the complete cohort and separately in women only to evaluate for gender-specific effects. Cortical thickness analyses were whole-brain corrected at the cluster-wise level; subcortical analyses were Bonferroni corrected. In women with FND, dismissing attachment correlated with reduced left parahippocampal cortical thickness. Confrontive coping was associated with reduced right hippocampal volume, while accepting responsibility positively correlated with right precentral gyrus cortical thickness. These findings held adjusting for anti-depressant use. All FND-related findings were within the normal range when compared to healthy women. These observations connect individual-differences in limbic-paralimbic and premotor structures to attachment and coping styles in FND. The relationship between parahippocampal thickness and dismissing attachment may indicate aberrant social-emotional and contextual appraisal in women with FND.
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DOI：
10.1016/j.jaac.2017.01.013
发表时间：
2017-04
影响因子：
13.3
作者：
Busso DS;McLaughlin KA;Brueck S;Peverill M;Gold AL;Sheridan MA
通讯作者：
Sheridan MA
影响因子：
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影响因子：
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作者：
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影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
影响因子：
2.6
作者：
Cronje, Gretha;Pretorius, Chrisma
通讯作者：
Pretorius, Chrisma