Circulating microRNAs as novel biomarkers in the diagnosis of prostate cancer: a systematic review and meta-analysis
Circulating microRNAs as novel biomarkers in the diagnosis of prostate cancer: a systematic review and meta-analysis
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循环 microRNA 作为诊断前列腺癌的新型生物标志物：系统评价和荟萃分析
DOI：
10.1007/s11255-016-1281-4
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发表时间：
2016-04
影响因子：
2
通讯作者：
Wang Fubing
中科院分区：
文献类型：
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作者：
Yin Changqing;Fang Cheng;Weng Hong;Yuan Chunhui;Wang Fubing
背景检测前列腺癌（PC）患者循环microRNAs（miRNAs）的诊断价值目前仍存在争议。因此，我们对已发表的文献进行了荟萃分析，以系统地评估循环miRNA在PC中的诊断潜力。方法在PubMed，Embase和中国国家知识基础设施数据库中检索符合条件的研究。使用随机效应模型合并敏感性和特异性，并用于绘制汇总受试者工作特征（SROC）曲线。所有分析均使用Stata 13.0软件和Meta-Disc 1.4 for windows.ResultsA共纳入10篇文章的荟萃分析，根据纳入标准。基于所有纳入研究的汇总结果显示，循环miRNA具有相对较好的诊断性能，在区分PC和对照方面的灵敏度为0.74，特异性为0.71，SROC曲线下面积（AUC）为0.77。此外，荟萃回归和亚组分析表明，多种循环miRNA检测显示出比单一检测更好的诊断性能，AUC从0.75上升到0.81。结果表明，与非白种人相比，白种人循环miRNAs检测对PC的诊断准确率更高，p值为0.0378。结论循环miRNAs检测在PC的早期诊断中具有潜在的应用价值，尤其是多种循环miRNAs联合检测。然而，仍需要大规模的前瞻性研究来进一步验证我们的发现。
BackgroundThe diagnostic value of circulating microRNAs (miRNAs) detection in prostate cancer (PC) patients is currently under debate. Thus, we performed this meta-analysis of published literature to systematically evaluate the diagnostic potential of circulating miRNAs in PC.MethodsEligible studies were searched in PubMed, Embase and Chinese National Knowledge Infrastructure databases. Sensitivity and specificity were pooled using a random-effects model and were used to plot the summary receiver operator characteristic (SROC) curve. All analyses were performed using the Stata 13.0 software and Meta-Disc 1.4 for windows.ResultsA total of ten articles were included for the meta-analysis according to the inclusion criteria. The pooled results based on all included studies showed circulating miRNAs have a relatively good diagnostic performance, with a sensitivity of 0.74, a specificity of 0.71 and an area under SROC curve (AUC) of 0.77 in indiscriminating PC from controls. Furthermore, meta-regression and subgroup analyses indicate that multiple circulating miRNAs detection displayed a better diagnostic performance than single one, with an AUC rising from 0.75 to 0.81. Additional interesting finding was that Caucasian-based circulating miRNAs assays could reach a higher accuracy compared with non-Caucasian-based one for PC with thepvalue of 0.0378.ConclusionOur results confirmed the potential use of circulating miRNAs in the early diagnosis of PC, especially the combination of multiple circulating miRNAs. However, large-scale prospective studies are still needed to further validate our findings.
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DOI：
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发表时间：
2014
期刊：
--
影响因子：
--
作者：
小島原典子;森實敏夫;中山健夫;福岡敏雄;河合富士美;佐藤康仁;吉田雅博;山口直人
通讯作者：
小島原典子;森實敏夫;中山健夫;福岡敏雄;河合富士美;佐藤康仁;吉田雅博;山口直人
DOI：
10.33589/13.6.0471
发表时间：
2003-03
期刊：
International Society of Hair Restoration Surgery
影响因子：
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作者：
Ian M. Thompson;P. Goodman;C. Tangen;M. S. Lucia;Gary J. Miller;Leslie G. Ford;Michael M. Lieber;R. D. Cespedes;James N. Atkins;Scott M. Lippman;Susie M. Carlin;Anne Ryan;Connie M Szczepanek;John J. Crowley;C. Coltman
通讯作者：
Ian M. Thompson;P. Goodman;C. Tangen;M. S. Lucia;Gary J. Miller;Leslie G. Ford;Michael M. Lieber;R. D. Cespedes;James N. Atkins;Scott M. Lippman;Susie M. Carlin;Anne Ryan;Connie M Szczepanek;John J. Crowley;C. Coltman
DOI：
10.1007/s13277-014-1638-1
发表时间：
2014-05
期刊：
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
影响因子：
--
作者：
Srivastava A;Goldberger H;Dimtchev A;Marian C;Soldin O;Li X;Collins SP;Suy S;Kumar D
通讯作者：
Kumar D
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
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作者：
Agaoglu, Fulya Yaman;Kovancilar, Muge;Gezer, Ugur
通讯作者：
Gezer, Ugur