Maladaptive plasticity in levodopa-induced dyskinesias and tardive dyskinesias: old and new insights on the effects of dopamine receptor pharmacology.
Maladaptive plasticity in levodopa-induced dyskinesias and tardive dyskinesias: old and new insights on the effects of dopamine receptor pharmacology.
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DOI：
10.3389/fneur.2014.00049
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发表时间：
2014
影响因子：
3.4
通讯作者：
Quattrone A
中科院分区：
文献类型：
--
作者：
Cerasa A;Fasano A;Morgante F;Koch G;Quattrone A
适应不良可塑性可以定义为人类大脑中异常可塑性变化导致的行为丧失甚至疾病症状的发展。在神经学或精神病学领域中，多动性运动障碍与适应不良的神经可塑性相关，其可以通过功能变化（如递质释放、受体调节和突触可塑性的增加）或解剖学修饰（如轴突再生、发芽、突触发生和神经发生）来表达。最近来自人类和动物模型的证据支持了这一假设，即这些现象可能取决于长期药物治疗引起的多巴胺周转率的改变。然而，目前尚不清楚这些改变的皮质可塑性机制如何以及在哪里被定位。这项研究提供了一个最新的概述这些问题，以及对该领域未来研究的一些思考，特别是集中在两个特定的疾病（左旋多巴引起的运动障碍在帕金森病患者和迟发性运动障碍在精神分裂症患者），其中现代神经影像学方法最近提供了新的基本见解。
Maladaptive plasticity can be defined as behavioral loss or even development of disease symptoms resulting from aberrant plasticity changes in the human brain. Hyperkinetic movement disorders, in the neurological or psychiatric realms, have been associated with maladaptive neural plasticity that can be expressed by functional changes such as an increase in transmitter release, receptor regulation, and synaptic plasticity or anatomical modifications such as axonal regeneration, sprouting, synaptogenesis, and neurogenesis. Recent evidence from human and animal models provided support to the hypothesis that these phenomena likely depend on altered dopamine turnover induced by long-term drug treatment. However, it is still unclear how and where these altered mechanisms of cortical plasticity may be localized. This study provides an up-to-date overview of these issues together with some reflections on future studies in the field, particularly focusing on two specific disorders (levodopa-induced dyskinesias in Parkinson’s disease patients and tardive dyskinesias in schizophrenic patients) where the modern neuroimaging approaches have recently provided new fundamental insights.
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影响因子：
4.1
作者：
Cerasa, Antonio;Salsone, Maria;Quattrone, Aldo
通讯作者：
Quattrone, Aldo
影响因子：
--
作者：
Cenci, M. Angela;Konradi, Christine
通讯作者：
Konradi, Christine
影响因子：
4.7
作者：
Ganos, Christos;Kuehn, Simone;Muenchau, Alexander
通讯作者：
Muenchau, Alexander
影响因子：
14.5
作者：
Ahmed, Imtiaz;Bose, Subrata K.;Brooks, David J.
通讯作者：
Brooks, David J.
影响因子：
9.9
作者：
Byl, NN;Merzenich, MM;Jenkins, WM
通讯作者：
Jenkins, WM