Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting.
Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting.
复制标题
DOI：
10.1002/advs.202103469
复制
发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Shastri VP
中科院分区：
文献类型：
--
作者：
Gu Y;Forget A;Shastri VP
3D生物打印（3DBP）具有克服传统组织工程缺陷所需的几个要素，例如先验地定义组织形状，并作为临床翻译的桥梁。3DBP的变革潜力取决于下一代生物墨水的发展，这些生物墨水具有临床应用的特性。为此，除了打印所必需的物理化学特性外，生物墨水还需要具有促再生特性，同时能够打印出具有特定生物功能的稳定结构，这些结构能够在植入后存活下来，并在体内进化成功能组织。以生物墨水为重点的挤压生物打印，这一观点的回顾提倡一个严格的生物学为基础的方法来工程生物墨水，强调效率，可重复性和精简的翻译过程，将临床终点的前沿和中心。提出了满足上述各种翻译水平（TRL1‐5）性能标准的下一代生物墨水工程蓝图和表征工具包。生物3D打印（3DBP）是一项很有前途的技术，可以作为临床翻译的桥梁。3DBP的转化潜力取决于下一代生物墨水的发展。翻译生物墨水需要具有促再生特性，同时能够打印出稳定的结构，使其能够在植入后存活并进化成功能组织。
3D‐bioprinting (3DBP) possesses several elements necessary to overcome the deficiencies of conventional tissue engineering, such as defining tissue shape a priori, and serves as a bridge to clinical translation. This transformative potential of 3DBP hinges on the development of the next generation of bioinks that possess attributes for clinical use. Toward this end, in addition to physicochemical characteristics essential for printing, bioinks need to possess proregenerative attributes, while enabling printing of stable structures with a defined biological function that survives implantation and evolves in vivo into functional tissue. With a focus on bioinks for extrusion‐based bioprinting, this perspective review advocates a rigorous biology‐based approach to engineering bioinks, emphasizing efficiency, reproducibility, and a streamlined translation process that places the clinical endpoint front and center. A blueprint for engineering the next generation of bioinks that satisfy the aforementioned performance criteria for various translational levels (TRL1‐5) and a characterization tool kit is presented. 3D‐bioprinting (3DBP) is a promising technology that serves as a bridge to clinical translation. The translational potential of 3DBP depends on the development of the next generation of bioinks. Translational bioinks need to possess proregenerative attributes, while enabling printing of stable structures that survive implantation and evolve into functional tissue.
登录
查看更多内容
影响因子：
4.6
作者：
Dong Y;Arif A;Olsson M;Cali V;Hardman B;Dosanjh M;Lauer M;Midura RJ;Hascall VC;Brown KL;Johnson P
通讯作者：
Johnson P
影响因子：
4.5
作者：
Coppens, D. G. M.;de Wilde, S.;Hoekman, J.
通讯作者：
Hoekman, J.
DOI：
10.1073/pnas.1412740111
发表时间：
2014-11-11
影响因子：
11.1
作者：
Blumenthal, Nils R.;Hermanson, Ola;Shastri, V. Prasad
通讯作者：
Shastri, V. Prasad
影响因子：
6.6
作者：
Ferris, Cameron J.;Gilmore, Kerry J.;Panhuis, Marc In Het
通讯作者：
Panhuis, Marc In Het
DOI：
10.1016/j.msec.2019.01.080
发表时间：
2019-06-01
影响因子：
7.9
作者：
Arya, Neha;Forget, Aurelien;Shastri, V. Prasad
通讯作者：
Shastri, V. Prasad