Association between sarcopenia and erectile dysfunction in males with type II diabetes mellitus
Association between sarcopenia and erectile dysfunction in males with type II diabetes mellitus
复制标题
II 型糖尿病男性肌肉减少症与勃起功能障碍之间的关联
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Arzu Baygül
中科院分区：
文献类型：
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作者：
S. Uçak;R. Sivritepe;O. Kara;E. Sevim;Damla Ortaboz;E. V. Küçük;Sabri Atay;Arzu Baygül
摘要背景：在中老年男性糖尿病人群中，肌肉减少症和勃起功能障碍（艾德）的患病率逐渐增高，严重影响身体功能、性功能和生活质量。本研究的目的是评估糖尿病性ED患者的肌肉减少症。方法：研究包括98例男性2型糖尿病（DM）患者，年龄18-80岁。获得血液化学和激素水平。对患者进行国际勃起功能指数（IIEF-5）问卷调查。根据IIEF-5评分将患者分为3组;评分5-10分表示重度艾德，评分11-20分表示中度艾德，评分21-25分表示无ED。获得肌肉质量、握力、计时起身和行走试验、上臂中围、小腿围和体重指数。使用MedCalc统计软件版本12.7.7进行统计分析。比较三组间的所有参数。结果如下：在纳入研究的98名患者中，84名患者患有重度肌肉减少症，13名患者患有中度肌肉减少症，而只有1名患者具有正常的肌肉质量。平均年龄56.59 ± 11.46岁。根据IIEF-5评分将患者分为三组，38例重度艾德，39例中度艾德，21例无ED。三组之间在握力、计时起身和行走测试评分、上臂中臂周长和小腿周长方面存在显著差异（均为p <0.05）。结论：糖尿病艾德患者虽然肌肉质量保持不变，但肌肉力量和体能下降。糖尿病合并重度和中度艾德ED患者的肌肉力量和体能较低。
Abstract Background: The prevalence rates for both sarcopenia and erectile dysfunction (ED) gradually increase in middle-aged and elderly diabetic male population and they impair physical functioning, sexual functioning, and quality of life. The aim of the present study was to evaluate the sarcopenia in patients with diabetic ED. Methods: The study included 98 male patients with type II diabetes mellitus (DM) aged 18–80 years. Blood chemistry and hormone levels were obtained. The International Index of Erectile Function (IIEF-5) questionnaire was administered to the patients. The patients were divided into three groups according to the IIEF-5 score; a score of 5–10 points indicated severe ED, a score of 11–20 indicated moderate ED, and a score of 21–25 points indicated no ED. The muscle mass, handgrip strength, timed up and go test, upper mid-arm circumference, calf circumference, and body mass index were obtained. The statistical analysis was performed using MedCalc Statistical Software version 12.7.7. All parameters were compared between the three groups. Results: Of 98 patients included in the study, 84 patients had severe sarcopenia, 13 had moderate sarcopenia, while only one patient had normal muscle mass. The mean age was 56.59 ± 11.46 years. When patients were divided into three groups according to IIEF-5 score, 38 had severe ED, 39 had moderate ED, and 21 had no ED. There was a significant difference between the three groups in terms of handgrip strength, timed up and go test scores, upper mid-arm circumference, and calf circumference (p < .05 for all). Conclusions: Although muscle mass remains unchanged, muscle strength and physical performance decrease in diabetic ED patients. Diabetic patients with severe and moderate ED have lower muscle strength and physical performance.
睾酮诱导豚鼠性二态性颞肌收缩蛋白亚型的变化。
DOI：
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发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Lyons,GE;Kelly,AM;Rubinstein,NA
通讯作者：
Rubinstein,NA
影响因子：
3.3
作者：
Lauretani, F;Russo, CR;Ferrucci, L
通讯作者：
Ferrucci, L