SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression.
SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression.
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SIRT1通过靶向LC3B和Fas的相互作用减轻高压下髓核细胞的凋亡
DOI：
10.1155/2021/2420969
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发表时间：
2021
影响因子：
--
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Zhuo Y;Wang H;Zou L;Wang Y;Hu Y;Li P;Zhou Q
Mechanical overloading-induced nucleus pulposus cell (NPC) apoptosis plays a core role in the pathogenesis of intervertebral disc degeneration. In this study, we investigated the involvement of mammalian silent information regulator 2 homolog (SIRT1) in NPC apoptosis under high-magnitude compression. Our results showed that high-magnitude compression aggravated cellular apoptosis and attenuated the expression levels of SIRT1 and microtubule-associated protein-1 light chain-3B (LC3B) in rat NPCs in a three-dimensional (3D) cell culture model and an in vivo rat tail compression model, whereas SIRT1 overexpression in NPCs partially reversed these indicators. Moreover, SIRT1 overexpression increased the formation of the LC3B/Fas complex, alleviated activation of the NF-κB pathway, and reduced NPC apoptosis. Finally, downregulation of LC3B partially activated the NF-κB pathway and aggravated NPC apoptosis. Overall, upregulation of SIRT1 increases formation of the LC3B/Fas complex, which contributes to suppression of NPC apoptosis by inhibiting the NF-κB pathway under high compressive stress.
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影响因子：
5.6
作者：
Qi, Wei;Ren, Dong;Bai, Xiaoliang
通讯作者：
Bai, Xiaoliang
Sirt6 过表达通过诱导椎间盘退变模型中的自噬抑制髓核细胞的衰老和凋亡
影响因子：
9
作者：
Chen J;Xie JJ;Jin MY;Gu YT;Wu CC;Guo WJ;Yan YZ;Zhang ZJ;Wang JL;Zhang XL;Lin Y;Sun JL;Zhu GH;Wang XY;Wu YS
通讯作者：
Wu YS
SIRT1 通过促进退变的人椎间盘髓核细胞的自噬来防止细胞凋亡。
影响因子：
4.6
作者：
Jiang W;Zhang X;Hao J;Shen J;Fang J;Dong W;Wang D;Zhang X;Shui W;Luo Y;Lin L;Qiu Q;Liu B;Hu Z
通讯作者：
Hu Z
影响因子：
4.9
作者：
Miyazaki S;Kakutani K;Yurube T;Maeno K;Takada T;Zhang Z;Kurakawa T;Terashima Y;Ito M;Ueha T;Matsushita T;Kuroda R;Kurosaka M;Nishida K
通讯作者：
Nishida K
DOI：
10.1146/annurev.pathol.4.110807.092250
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Haigis MC;Sinclair DA
通讯作者：
Sinclair DA