FETAL NEURONAL GRAFTS IN MONKEYS GIVEN METHYLPHENYLTETRAHYDROPYRIDINE
FETAL NEURONAL GRAFTS IN MONKEYS GIVEN METHYLPHENYLTETRAHYDROPYRIDINE
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给予甲基苯基四氢吡啶的猴子胎儿神经元移植物
DOI：
10.1016/s0140-6736(86)91839-8
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Haber
中科院分区：
文献类型：
--
作者：
D. Redmond;R. Roth;J. Elsworth;J. Sladek;T. Collier;A. Deutch;S. Haber
两个不同胎龄的胎儿黑质细胞成功移植到三只患有严重帕金森运动和行为缺陷的甲基苯基四氢吡啶治疗的猴子的大脑中。在将细胞移植到两只猴子的纹状体后，功能改善持续了10周，在尸检中发现大量酪氨酸-羟化酶阳性的胎儿神经元。行为改善与移植后脑脊液（CSF）高香草酸（HVA）浓度的增加相关。另一只被不恰当地移植了较早孕龄细胞的对照猴仍然患有严重的帕金森病，并在类似的时间内死亡。这只猴子的脑脊液HVA较移植前的低水平略有下降。两种不同胎龄的胎儿多巴胺神经元似乎在灵长类动物移植中存活，并具有生化和功能影响。
Fetal substantia nigra cells of two different gestational ages were successfully transplanted into the brains of three methylphenyltetra-hydropyridine-treated monkeys with severe parkinsonian motor and behavioural deficits. Functional improvement continued for 10 weeks after cell grafts into the striata of two monkeys with substantial numbers of tyrosine-hydroxylase-positive fetal neurons at necropsy. Behavioural improvement was correlated with increases in cerebrospinal fluid (CSF) homovanillic acid (HVA) concentrations after the transplants. A control monkey with inappropriately placed transplanted cells of an earlier gestational age remained severely parkinsonian and died during a similar period. CSF HVA fell slightly in this monkey from the low level seen before the transplants. Fetal dopamine neurons of two different gestational ages appear to survive transplantation in primates and have biochemical and functional effects.
移植的加压素神经元的功能发育。
DOI：
10.1126/science.7434031
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gash,D;SladekJr,JR;Sladek,CD
通讯作者：
Sladek,CD