The Spatiotemporal Organization of the Striatum Encodes Action Space.
The Spatiotemporal Organization of the Striatum Encodes Action Space.
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DOI：
10.1016/j.neuron.2017.08.015
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发表时间：
2017-08-30
期刊：
影响因子：
16.2
通讯作者：
Costa RM
中科院分区：
文献类型：
--
作者：
Klaus A;Martins GJ;Paixao VB;Zhou P;Paninski L;Costa RM
纹状体直接和间接通路棘投射神经元（SPN）的活动对于正确的运动至关重要。然而，很少有人知道的时空组织这一活动。我们研究了小鼠自发性自然运动过程中SPN整体活动的时空组织，使用显微内窥镜成像。这两种途径的活性主要表现为局部相关，但也有一些长程相关。使用一种基于连续加速度计和视频数据的聚类和量化行为的新方法，我们发现在特定动作期间活动的SPN集合在空间上更接近，整体上更相关。此外，不同的动作之间的相似性对应的SPN集成模式之间的相似性，无论运动速度。因此，从SPN集成模式解码行为的准确性与行为集群之间的差异直接相关。这些结果确定了一个主要的本地，但不是空间紧凑，组织的直接和间接途径的SPN活动，映射动作空间独立的运动速度。直接和间接路径SPN显示局部偏置时空组织SPN活动在特定的行为是更加相关和空间上更接近SPN合奏编码动作身份独立于移动速度之间的距离行为对应于SPN合奏模式之间的距离克劳斯，马丁斯等人。在自主调节、自然行为过程中来自背侧纹状体直接和间接通路神经元的成像神经活动。他们发现，纹状体神经元形成时空组织的集合，并独立于运动速度映射动作空间。
Activity in striatal direct- and indirect-pathway spiny projection neurons (SPNs) is critical for proper movement. However, little is known about the spatiotemporal organization of this activity. We investigated the spatiotemporal organization of SPN ensemble activity in mice during self-paced, natural movements using microendoscopic imaging. Activity in both pathways showed predominantly local but also some long-range correlations. Using a novel approach to cluster and quantify behaviors based on continuous accelerometer and video data, we found that SPN ensembles active during specific actions were spatially closer and more correlated overall. Furthermore, similarity between different actions corresponded to the similarity between SPN ensemble patterns, irrespective of movement speed. Consistently, the accuracy of decoding behavior from SPN ensemble patterns was directly related to the dissimilarity between behavioral clusters. These results identify a predominantly local, but not spatially compact, organization of direct- and indirect-pathway SPN activity that maps action space independently of movement speed. Direct- and indirect-pathway SPNs show locally biased spatiotemporal organization SPNs active during a particular behavior are more correlated and spatially closer SPN ensembles encode action identity independently of movement speed Distance between behaviors corresponds to distance between SPN ensemble patterns Klaus, Martins et al. image neural activity from direct- and indirect-pathway neurons of dorsal striatum during self-paced, natural behaviors. They find that striatal neurons form ensembles that are spatiotemporally organized and map action space independently of movement speed.
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