Selective recognition of HIV RNA by dinuclear metallic ligands

Selective recognition of HIV RNA by dinuclear metallic ligands
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双核金属配体选择性识别 HIV RNA

DOI:
10.1016/j.cclet.2018.06.003
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发表时间:
2018-11
影响因子:
9.1
通讯作者:
Cheng Liang
Cheng Liang
中科院分区:
化学1区
文献类型:
--
作者:
Li Xuedong;Chen Bo;Lan Ling;Wang Ruili;Luo Duqiang;Liu Li;Cheng Liang

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We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties.
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