Peripheral neuropathy and tear film dysfunction in type 1 diabetes mellitus.
Peripheral neuropathy and tear film dysfunction in type 1 diabetes mellitus.
复制标题
DOI：
10.1155/2014/848659
复制
发表时间：
2014
影响因子：
4.3
通讯作者：
Craig JP
中科院分区：
文献类型：
--
作者：
Misra SL;Patel DV;McGhee CN;Pradhan M;Kilfoyle D;Braatvedt GD;Craig JP
目的。比较1型糖尿病（DM）患者与健康对照者的泪膜指标，探讨周围神经病变与眼表质量的关系。方法。对53例1型糖尿病患者和40例年龄匹配的对照组进行干眼症状量化。眼部检查包括泪膜脂质层厚度分级、泪膜稳定性和数量测量、视网膜摄影。糖尿病患者还接受了详细的神经病变评估。结果。DM组和对照组的平均年龄和干眼症状评分均无显著差异（P = 0.12和P = 0.33）。DM组泪液脂质厚度（P = 0.02）、稳定性（P < 0.0001）、数量（P = 0.01）均显著降低。DM组角膜敏感性也降低（P < 0.001），泪膜稳定性与总神经病变评分呈负相关（r = - 0.29, P = 0.03）。结论。与年龄匹配的对照组相比，DM组泪膜稳定性、分泌量和脂质层质量明显降低。泪膜参数与总神经病变评分呈负相关，提示眼表异常与糖尿病周围神经病变同时发生。
Purpose. To compare tear film metrics in patients with type 1 diabetes mellitus (DM) and healthy controls and investigate the association between peripheral neuropathy and ocular surface quality. Methods. Dry eye symptoms were quantified in 53 patients with type 1 DM and 40 age-matched controls. Ocular examination included tear film lipid layer thickness grading, tear film stability and quantity measurement, and retinal photography. DM individuals additionally underwent a detailed neuropathy assessment. Results. Neither mean age nor dry eye symptom scores differed significantly between the DM and control groups (P = 0.12 and P = 0.33, resp.). Tear lipid thickness (P = 0.02), stability (P < 0.0001), and quantity (P = 0.01) were significantly lower in the DM group. Corneal sensitivity was also reduced in the DM group (P < 0.001) and tear film stability was inversely associated with total neuropathy score (r = −0.29, P = 0.03). Conclusion. The DM group exhibited significantly reduced tear film stability, secretion, and lipid layer quality relative to the age-matched control group. The negative correlation between tear film parameters and total neuropathy score suggests that ocular surface abnormalities occur in parallel with diabetic peripheral neuropathy.
登录
查看更多内容
影响因子：
1.4
作者：
Craig, JP;Tomlinson, A
通讯作者：
Tomlinson, A
影响因子：
9.9
作者：
Cornblath, DR;Chaudhry, V;Joh, T
通讯作者：
Joh, T
影响因子：
6.4
作者：
Buchholz, Patricia;Steeds, Carolyn S.;Figueiredo, Francisco C.
通讯作者：
Figueiredo, Francisco C.
DOI：
10.1016/s1367-0484(98)80035-0
发表时间：
1998-01-01
期刊：
Contact lens & anterior eye : the journal of the British Contact Lens Association
影响因子：
--
作者：
Guillon, J P
通讯作者：
Guillon, J P
影响因子：
2.8
作者：
Patel, Dipika V.;Tavakoli, Mitra;McGhee, Charles N. J.
通讯作者：
McGhee, Charles N. J.