HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype.
HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype.
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DOI：
10.1016/j.chom.2022.06.005
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发表时间：
2022-08-10
影响因子：
30.3
通讯作者：
Thomas, Rasmi
中科院分区：
文献类型：
--
作者：
Li, Shuying S.;Hickey, Andrew;Shangguan, Shida;Ehrenberg, Philip K.;Geretz, Aviva;Butler, Lauryn;Kundu, Gautam;Apps, Richard;Creegan, Matthew;Clifford, Robert J.;Pinyakorn, Suteeraporn;Eller, Leigh Anne;Luechai, Pikunchai;Gilbert, Peter B.;Holtz, Timothy H.;Chitwarakorn, Anupong;Sacdalan, Carlo;Kroon, Eugene;Phanuphak, Nittaya;de Souza, Mark;Ananworanich, Jintanat;O'Connell, Robert J.;Robb, Merlin L.;Michael, Nelson L.;Vasan, Sandhya;Thomas, Rasmi
人类白细胞抗原（HLA）等位基因与HIV疾病进展有关，并归因于细胞毒性T淋巴细胞（CTL）表位表征的差异。这些发现主要是基于欧洲和非洲血统的未接受治疗的个体。我们评估了来自泰国的1,318个人的HLA与HIV-1结局的关系，发现HLA-B*46:01 （B*46）与三个独立队列中的疾病加速相关。B*46对hiv特异性T细胞反应没有可检测到的影响，但这种等位基因在含有与自然杀伤（NK）细胞上的抑制性受体结合的HLA-C表位方面是不寻常的。无偏倚转录组筛选显示，没有B*46的HIV感染者NK细胞活化增加，同时单细胞表面蛋白和转录组分析显示，在没有B*46的情况下，NK细胞亚群的反应增加。这些发现支持NK细胞在HIV发病机制中的作用，这是由仅在亚洲常见的B*46等位基因的独特特性揭示的。Li等人在三个独立的队列中表明，泰国最常见的HLA-B等位基因B*46与HIV疾病进展有关。这可能是由于NK细胞群的差异，特别是在HLA-B*46患者中发现的具有活化表型的亚群。
Human leukocyte antigen (HLA) alleles have been linked to HIV disease progression and attributed to differences in cytotoxic T lymphocyte (CTL) epitope representation. These findings are largely based on treatment-naive individuals of European and African ancestry. We assessed HLA associations with HIV-1 outcomes in 1,318 individuals from Thailand and found HLA-B*46:01 (B*46) associated with accelerated disease in three independent cohorts. B*46 had no detectable effect on HIV-specific T cell responses, but this allele is unusual in containing an HLA-C epitope that binds inhibitory receptors on natural killer (NK) cells. Unbiased transcriptomic screens showed increased NK cell activation in people with HIV, without B*46, and simultaneous single-cell profiling of surface proteins and transcriptomes revealed a NK cell subset primed for increased responses in the absence of B*46. These findings support a role for NK cells in HIV pathogenesis, revealed by the unique properties of the B*46 allele common only in Asia. Li et al. show that B*46, the most frequent HLA-B allele in Thailand, is associated with HIV disease progression in three independent cohorts. This may result from differences in NK cell populations, specifically a subset with an activated phenotype that was found to be absent in people with HLA-B*46.
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影响因子：
3.7
作者：
Leelawiwat W;Pattanasin S;Sriporn A;Wasinrapee P;Kongpechsatit O;Mueanpai F;Tongtoyai J;Holtz TH;Curlin ME
通讯作者：
Curlin ME
影响因子：
158.5
作者：
Gao, XJ;Nelson, GW;Carrington, M
通讯作者：
Carrington, M
影响因子：
15.3
作者：
Barber, LD;Percival, L;Parham, P
通讯作者：
Parham, P
HIV-1 疫苗功效试验的免疫相关分析。
DOI：
10.1056/nejmoa1113425
发表时间：
2012-04-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Haynes BF;Gilbert PB;McElrath MJ;Zolla-Pazner S;Tomaras GD;Alam SM;Evans DT;Montefiori DC;Karnasuta C;Sutthent R;Liao HX;DeVico AL;Lewis GK;Williams C;Pinter A;Fong Y;Janes H;DeCamp A;Huang Y;Rao M;Billings E;Karasavvas N;Robb ML;Ngauy V;de Souza MS;Paris R;Ferrari G;Bailer RT;Soderberg KA;Andrews C;Berman PW;Frahm N;De Rosa SC;Alpert MD;Yates NL;Shen X;Koup RA;Pitisuttithum P;Kaewkungwal J;Nitayaphan S;Rerks-Ngarm S;Michael NL;Kim JH
通讯作者：
Kim JH
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y