Association between HIV genotype, viral load and disease progression in a cohort of Thai men who have sex with men with estimated dates of HIV infection.
Association between HIV genotype, viral load and disease progression in a cohort of Thai men who have sex with men with estimated dates of HIV infection.
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在一组与估计艾滋病毒感染日期的男性发生性关系的泰国男性中，艾滋病毒基因型、病毒载量和疾病进展之间的关联。
DOI：
10.1371/journal.pone.0201386
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Curlin ME
中科院分区：
文献类型：
--
作者：
Leelawiwat W;Pattanasin S;Sriporn A;Wasinrapee P;Kongpechsatit O;Mueanpai F;Tongtoyai J;Holtz TH;Curlin ME
艾滋病毒基因型之间的差异可能会影响艾滋病毒疾病的进展。我们在泰国曼谷的一群与HIV感染者发生性关系的男性中研究了感染HIV基因型及其与疾病进展的关系。我们使用杂交和测序技术对2006-2014年间在MSM中发现的189例新的HIV感染者的病毒基因型进行了表征。采用PCR法检测血浆病毒载量（PVL），流式细胞术检测CD 4 + T细胞计数。我们使用广义估计方程来检查与CD 4 + T细胞计数变化相关的因素。使用考克斯比例风险模型分析与免疫失败相关的因素。189例MSM中，CRF01_AE感染率为84%，重组B/CRF01_AE感染率为11%，B亚型感染率为5%。CRF01_AE、重组体和亚型B的CD 4 + T细胞下降率分别为68、65和46个细胞/μL/年，HIV亚型之间无显著差异。CD 4 + T细胞下降率与基线PVL和CD 4 + T细胞计数显著相关（p <0.001）。进展至免疫失败与基线CD 4 + T细胞≤ 500个细胞/μL（AHR 1.97; 95% CI 1.14-3.40，p = 0.015）和PVL > 50，000拷贝/ml（AHR 2.03; 1.14-3.63，p = 0.017）相关。HIV亚型之间的免疫失败时间没有差异。在HIV感染的泰国MSM中，低基线CD 4 + T细胞和高PVL与快速进展相关。在该队列中，CRF01_AE和其他感染HIV亚型之间的CD 4 + T细胞下降率或至免疫失败时间无显著差异。
Differences between HIV genotypes may affect HIV disease progression. We examined infecting HIV genotypes and their association with disease progression in a cohort of men who have sex with men with incident HIV infection in Bangkok, Thailand. We characterized the viral genotype of 189 new HIV infections among MSM identified between 2006–2014 using hybridization and sequencing. Plasma viral load (PVL) was determined by PCR, and CD4+ T-cell counts were measured by flow cytometry. We used Generalized Estimating Equations to examine factors associated with changes in CD4+ T-cell counts. Factors associated with immunologic failure were analyzed using Cox proportional hazard models. Among 189 MSM, 84% were infected with CRF01_AE, 11% with recombinant B/CRF01_AE and 5% with subtype B. CD4+ T-cell decline rates were 68, 65, and 46 cells/μL/year for CRF01_AE, recombinants, and subtype B, respectively, and were not significantly different between HIV subtypes. CD4+ T-cell decline rate was significantly associated with baseline PVL and CD4+ T-cell counts (p <0.001). Progression to immunologic failure was associated with baseline CD4+ T-cell ≤ 500 cells/μL (AHR 1.97; 95% CI 1.14–3.40, p = 0.015) and PVL > 50,000 copies/ml (AHR 2.03; 1.14–3.63, p = 0.017). There was no difference in time to immunologic failure between HIV subtypes. Among HIV-infected Thai MSM, low baseline CD4+ T-cell and high PVL are associated with rapid progression. In this cohort, no significant difference in CD4+ T-cell decline rate or time to immunologic failure was seen between CRF01_AE and other infecting HIV subtypes.
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影响因子：
56.9
作者：
Carrington, M;Nelson, GW;O'Brien, SJ
通讯作者：
O'Brien, SJ
影响因子：
3.7
作者：
Kijak, Gustavo H.;Tovanabutra, Sodsai;McCutchan, Francine E.
通讯作者：
McCutchan, Francine E.
DOI：
10.1097/qad.0000000000000012
发表时间：
2013-11-13
期刊：
AIDS (London, England)
影响因子：
--
作者：
Amornkul PN;Karita E;Kamali A;Rida WN;Sanders EJ;Lakhi S;Price MA;Kilembe W;Cormier E;Anzala O;Latka MH;Bekker LG;Allen SA;Gilmour J;Fast PE;IAVI Africa HIV Prevention Partnership
通讯作者：
IAVI Africa HIV Prevention Partnership
影响因子：
6.4
作者：
Baeten, Jared M.;Chohan, Bhavna;Overbaugh, Julie
通讯作者：
Overbaugh, Julie
影响因子：
168.9
作者：
Choopanya, Kachit;Martin, Michael;Vanichseni, Suphak
通讯作者：
Vanichseni, Suphak