Is transcranial alternating current stimulation effective in modulating brain oscillations?
Is transcranial alternating current stimulation effective in modulating brain oscillations?
复制标题
DOI：
10.1371/journal.pone.0056589
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Miniussi C
中科院分区：
文献类型：
--
作者：
Brignani D;Ruzzoli M;Mauri P;Miniussi C
经颅交流电刺激（tACS）是一种很有前途的调节大脑振荡的工具，也是一种可能的治疗干预手段。然而，缺乏关于tACS是否能够有效影响皮质活动的确凿证据继续限制其应用。本研究旨在通过利用视觉感知和注意定向过程中后顶叶皮层中众所周知的抑制性α节律来解决这一问题。对四组健康志愿者进行Gabor贴片检测和识别任务。所有参与者都在基线和tACS的选择频率下进行测试，包括Sham， 6 Hz， 10 Hz和25 Hz。与基线相比，枕顶区6hz和10hz的刺激会损害检测任务的表现。在检测任务中缺乏视网膜组织效应和边际频率特异性调制使我们对tACS调节脑振荡的有效性持谨慎态度。因此，目前的研究并没有提供重要的证据，证明tACS可以可靠地诱导直接调节大脑振荡，从而影响视觉任务的表现。
Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations, as well as a possible therapeutic intervention. However, the lack of conclusive evidence on whether tACS is able to effectively affect cortical activity continues to limit its application. The present study aims to address this issue by exploiting the well-known inhibitory alpha rhythm in the posterior parietal cortex during visual perception and attention orientation. Four groups of healthy volunteers were tested with a Gabor patch detection and discrimination task. All participants were tested at the baseline and selective frequencies of tACS, including Sham, 6 Hz, 10 Hz, and 25 Hz. Stimulation at 6 Hz and 10 Hz over the occipito-parietal area impaired performance in the detection task compared to the baseline. The lack of a retinotopically organised effect and marginal frequency-specificity modulation in the detection task force us to be cautious about the effectiveness of tACS in modulating brain oscillations. Therefore, the present study does not provide significant evidence for tACS reliably inducing direct modulations of brain oscillations that can influence performance in a visual task.
登录
查看更多内容
影响因子：
5.3
作者：
Busch, Niko A.;Dubois, Julien;VanRullen, Rufin
通讯作者：
VanRullen, Rufin
影响因子：
2.9
作者：
Bolognini, Nadia;Fregni, Felipe;Vallar, Giuseppe
通讯作者：
Vallar, Giuseppe
影响因子：
2.5
作者：
Bastiaansen, Marcel C. M.;Oostenveld, Robert;Hagoort, Peter
通讯作者：
Hagoort, Peter
影响因子：
4.4
作者：
Antal, A;Kincses, TZ;Paulus, W
通讯作者：
Paulus, W
影响因子：
4.7
作者：
Antal, Andrea;Terney, Daniella;Paulus, Walter
通讯作者：
Paulus, Walter