Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation.
Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation.
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DOI：
10.1016/j.jpeds.2012.01.011
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发表时间：
2012-07
影响因子：
5.1
通讯作者：
Hirsch, Raphael
中科院分区：
文献类型：
--
作者：
Gorelik, Mark;Wilson, David C.;Cloonan, Yona K.;Shulman, Stanford T.;Hirsch, Raphael
确定血浆卵泡抑素样蛋白1（FSTL-1）（一种由间质组织（包括心肌细胞）产生的促炎蛋白）水平是否与川崎（KD）和冠状动脉瘤（CAA）的发生相关。在48例KD患者中，在诊断时以及发病后2周、6周和6个月（如果可用），通过ELISA连续测量FSTL-1血浆水平。与23个对照组进行了比较。使用广义估计方程对数据进行分析。与对照组相比，急性KD患者的血浆FSTL-1水平升高（p=0.0086）。FSTL-1水平在发病后2周仍显著升高，但在6个月时恢复至对照水平。7例CAA患者在诊断时的FSTL-1水平显著高于未发生动脉瘤的患者（p=0.0018）。以FSTL-1为界值（178 ng/ml）诊断CAA的敏感性和特异性分别为85%和71%。FSTL-1的血浆水平在急性KD中升高，并且可以预测这种疾病的心脏病发病率。这些结果表明FSTL-1在冠状动脉瘤的形成中可能起作用。
To determine if plasma levels of follistatin-like protein 1 (FSTL-1), a pro-inflammatory protein produced by mesenchymal tissue, including cardiac myocytes, correlate with the development of Kawasaki disease (KD) and coronary artery aneurysms (CAA). FSTL-1 plasma levels were measured serially by ELISA in 48 patients with KD at time of diagnosis and, when available, 2 weeks, 6 weeks and 6 months following onset of disease. These were compared with 23 controls. Data were analyzed using Generalized Estimating Equations. Plasma FSTL-1 levels were elevated in patients with acute KD as compared with controls (p=0.0086). FSTL-1 levels remained significantly elevated at 2 weeks after disease onset but returned to control levels by 6 months. Seven patients with CAA had significantly higher FSTL-1 levels at the time of diagnosis than those who did not develop aneurysms (p=0.0018). Sensitivity and specificity for CAA at a specific FSTL-1 cutpoint (178ng/ml) was 85% and 71%. Plasma levels of FSTL-1 are elevated in acute KD and may predict cardiac morbidity in this disease. These results suggest a possible role for FSTL-1 in the formation of coronary artery aneurysms.
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影响因子：
24
作者：
Printz, Beth F;Sleeper, Lynn A;Newburger, Jane W;Minich, L LuAnn;Bradley, Timothy;Cohen, Meryl S;Frank, Deborah;Li, Jennifer S;Margossian, Renee;Shirali, Girish;Takahashi, Masato;Colan, Steven D
通讯作者：
Colan, Steven D
影响因子：
4.4
作者：
Miyamae, Takako;Marinov, Anthony D.;Hirsch, Raphael
通讯作者：
Hirsch, Raphael
影响因子：
3.6
作者：
Song, DooIl;Yeo, Yunku;Lee, JooWon
通讯作者：
Lee, JooWon
影响因子：
4.8
作者：
Ouchi, Noriyuki;Oshima, Yuichi;Walsh, Kenneth
通讯作者：
Walsh, Kenneth
DOI：
10.4049/jimmunol.182.1.234
发表时间：
2009-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Clutter SD;Wilson DC;Marinov AD;Hirsch R
通讯作者：
Hirsch R