Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions.
Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions.
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痛苦的椎间盘退变和炎症：从实验室证据到临床干预
DOI：
10.1038/s41413-020-00125-x
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发表时间：
2021-01-29
期刊：
影响因子：
12.7
通讯作者：
Zheng Z
中科院分区：
文献类型：
--
作者：
Lyu FJ;Cui H;Pan H;Mc Cheung K;Cao X;Iatridis JC;Zheng Z
腰痛（LBP）是一种常见的肌肉骨骼疾病，是导致残疾的主要原因，造成了重大的社会和经济负担。最近的研究发现，炎症和相关信号通路是椎间盘退变发生和进展的重要因素，是腰痛的重要诱因。炎症介质在椎间盘源性腰痛中也起着不可或缺的作用。抑制腰痛是临床实践的主要目标，但在椎间盘研究中尚未得到足够的重视。本文综述了椎间盘退变中炎症相关疼痛的研究进展，并讨论了炎症在IVD退变和疼痛诱导中的作用。讨论了针刺模型、力学模型和自发模型作为研究疼痛性椎间盘退变的主要动物模型，并总结了其潜在的信号通路。此外，潜在的候选药物，无论是实验室研究还是正在进行临床试验，探索通过消除炎症来抑制盘源性腰痛。我们希望吸引更多的研究兴趣来解决IDD中的炎症和疼痛，并为促进更多的转化研究做出贡献。
Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration, a significant contributor to LBP. Inflammatory mediators also play an indispensable role in discogenic LBP. The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies. Here, an overview of the advances in inflammation-related pain in disc degeneration is provided, with a discussion on the role of inflammation in IVD degeneration and pain induction. Puncture models, mechanical models, and spontaneous models as the main animal models to study painful disc degeneration are discussed, and the underlying signaling pathways are summarized. Furthermore, potential drug candidates, either under laboratory investigation or undergoing clinical trials, to suppress discogenic LBP by eliminating inflammation are explored. We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research.
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影响因子：
12.7
作者：
Bian Q;Ma L;Jain A;Crane JL;Kebaish K;Wan M;Zhang Z;Edward Guo X;Sponseller PD;Séguin CA;Riley LH;Wang Y;Cao X
通讯作者：
Cao X
影响因子：
2.3
作者：
Akeda K;Ohishi K;Masuda K;Bae WC;Takegami N;Yamada J;Nakamura T;Sakakibara T;Kasai Y;Sudo A
通讯作者：
Sudo A
影响因子：
4.9
作者：
Clarke LE;McConnell JC;Sherratt MJ;Derby B;Richardson SM;Hoyland JA
通讯作者：
Hoyland JA
影响因子：
12.8
作者：
Cho, Hongsik;Park, Sang-Hyug;Kim, Song-Ja
通讯作者：
Kim, Song-Ja
DOI：
10.2106/00004623-199072030-00013
发表时间：
1990-03-01
影响因子：
5.3
作者：
BODEN, SD;DAVIS, DO;WIESEL, SW
通讯作者：
WIESEL, SW