Association of CHRN genes with "dizziness" to tobacco.
Association of CHRN genes with "dizziness" to tobacco.
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DOI：
10.1002/ajmg.b.31027
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发表时间：
2010-03-05
影响因子：
2.8
通讯作者：
Bierut, Laura J.
中科院分区：
文献类型：
--
作者：
Ehringer, Marissa A.;McQueen, Matthew B.;Hoft, Nicole R.;Saccone, Nancy L.;Stitzel, Jerry A.;Wang, Jen C.;Bierut, Laura J.
神经元烟碱受体基因（CHRN）参与了多种与吸烟相关的行为。在这里，我们测试了早期主观反应表型“头晕”和CHRN基因中的226个SNP之间的关联。样本包括789例尼古丁依赖病例和811例对照，其中早期“头晕”报告与病例/对照状态显著相关（p<0.0001）。CHRNB 3基因启动子区域的多个SNP与最初几支香烟的“头晕”体验名义上相关（p<0.01）。进行细胞培养研究以检查CHRNB 3启动子中不同单倍型驱动荧光素酶表达的能力。来自这些实验的数据支持CHRNB 3上游启动子区域中的不同等位基因可能导致不同水平的RNA表达的假设。此外，CHRNA 10基因中SNP之间的关联的新发现达到了实验范围内的经验显著性（p=0.048），这暗示另一个CHRN基因参与了对烟草的早期主观反应。
The neuronal nicotinic receptor genes (CHRN) have been implicated in a variety of smoking-related behaviors. Here we tested for association between an early subjective response phenotype, “dizziness,” and 226 SNPs in CHRN genes. The sample included 789 nicotine-dependent cases and 811 controls, where early “dizziness” reports were significantly associated with case/control status (p<0.0001). Multiple SNPs in the putative promoter region of the CHRNB3 gene were nominally associated with “dizziness” experience from the first few cigarettes (p<0.01). Cell culture studies were conducted to examine the ability of different haplotypes in the CHRNB3 promoter to drive luciferase expression. Data from these experiments supports the hypothesis that different alleles in the CHRNB3 upstream promoter region may lead to different levels of RNA expression. In addition, a novel finding of association between SNPs in the CHRNA10 gene reached experiment-wide empirical significance (p=0.048), which implicates another CHRN gene as being involved in early subjective response to tobacco.
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影响因子：
4.4
作者：
Lustig, LR;Peng, H;Fuchs, PA
通讯作者：
Fuchs, PA
DOI：
10.1038/npp.2008.122
发表时间：
2009-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
56.9
作者：
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通讯作者：
Altshuler, D
影响因子：
64.8
作者：
Hung, Rayjean J.;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
5.8
作者：
Gotti, Cecilia;Moretti, Milena;Zoli, Michele
通讯作者：
Zoli, Michele