Dendritic cells and aging: consequences for autoimmunity.
Dendritic cells and aging: consequences for autoimmunity.
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DOI：
10.1586/eci.11.77
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发表时间：
2012-01
影响因子：
4.4
通讯作者：
Agrawal H
中科院分区：
文献类型：
--
作者：
Agrawal A;Sridharan A;Prakash S;Agrawal H
免疫系统已经进化到对外来病原体产生免疫反应，并对自身抗原保持沉默。需要免疫和耐受之间的平衡，因为任何干扰都可能导致慢性炎症或自身免疫。树突状细胞（DC）积极参与维持这种平衡。在稳态条件下，DC保持不成熟状态，并且不对外周中的循环自身抗原产生免疫应答，这维持耐受状态。相反，外源抗原导致DC成熟和DC诱导的T细胞活化。由于感染或组织损伤导致的DC的不适当成熟可能导致DC的致耐受性和免疫原性功能之间的平衡改变，并引发自身免疫性疾病的发展。本文综述了年龄增长对DC功能的影响及其在自身免疫中的意义。
The immune system has evolved to mount immune responses against foreign pathogens and to remain silent against self-antigens. A balance between immunity and tolerance is required as any disturbance may result in chronic inflammation or autoimmunity. Dendritic cells (DCs) actively participate in maintaining this balance. Under steady-state conditions, DCs remain in an immature state and do not mount an immune response against circulating self-antigens in the periphery, which maintains a state of tolerance. By contrast, foreign antigens result in DC maturation and DC-induced T-cell activation. Inappropriate maturation of DCs due to infections or tissue injury may cause alterations in the balance between the tolerogenic and immunogenic functions of DCs and instigate the development of autoimmune diseases. This article provides an overview of the effects of advancing age on DC functions and their implications in autoimmunity.
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影响因子：
13.6
作者：
Boren, E;Gershwin, ME
通讯作者：
Gershwin, ME
影响因子：
4.6
作者：
Aprahamian, T.;Takemura, Y.;Walsh, K.
通讯作者：
Walsh, K.
CD8α(+)树突状细胞负责诱导外周组织相关抗原的自身耐受。
影响因子：
15.3
作者：
Belz, Gabrielle T;Behrens, Georg M N;Smith, Chris M;Miller, Jacques F A P;Jones, Claerwen;Lejon, Kristina;Fathman, C Garrison;Mueller, Scott N;Shortman, Ken;Carbone, Francis R;Heath, William R
通讯作者：
Heath, William R
影响因子：
56.9
作者：
Blanco, P;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J
影响因子：
5.4
作者：
Bhatnagar, Harshita;Kala, Smriti;Pal, Rahul
通讯作者：
Pal, Rahul