Marker of peripheral blood granulocytes and monocytes of man recognized by two monoclonal antibodies VEP8 and VEP9 involves the trisaccharide 3‐fucosyl‐N‐acetyllactosamine
Marker of peripheral blood granulocytes and monocytes of man recognized by two monoclonal antibodies VEP8 and VEP9 involves the trisaccharide 3‐fucosyl‐N‐acetyllactosamine
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两种单克隆抗体 VEP8 和 VEP9 识别的人外周血粒细胞和单核细胞标记物涉及三糖 3-岩藻糖基-N-乙酰基乳糖胺
DOI：
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发表时间：
1983
影响因子：
5.4
通讯作者：
T. Feizi
中科院分区：
文献类型：
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作者：
H. Gooi;S. Thorpe;E. Hounsell;H. Rumpold;D. Kraft;O. Förster;T. Feizi
针对早幼粒单核细胞白血病细胞系HL 60产生的两种杂交瘤抗体（VEP 8和VEP 9）先前已显示出将人粒细胞和单核细胞与外周血的其它细胞区分开。我们在此报告，两种抗体均识别具有以下序列的碳水化合物结构3-岩藻糖基-N-乙酰乳糖胺：该结构与抗小鼠畸胎瘤细胞的杂交瘤抗体（抗SSEA-1）识别的结构相同，后者识别小鼠中的早期胚胎抗原。直到最近，这种碳水化合物结构被认为是糖蛋白和鞘糖脂中罕见的。然而，有越来越多的人类和动物糖蛋白，其中该序列已通过化学和免疫化学方法检测到。在这篇文章中，我们调查了这些信息，并讨论了这种和其他碳水化合物结构如何作为分化或肿瘤相关抗原。
Two hybridoma antibodies (VEP8 and VEP9) raised against the promyelomonocytic leukemia cell line HL60 have previously been shown to distinguish human granulocytes and monocytes from other cells of the peripheral blood. We report here that both antibodies recognize the carbohydrate structure 3‐fucosyl‐N‐acetyllactosamine with the following sequence: This structure is the same as that recognized by a hybridoma antibody against mouse teratocarcinoma cells (anti‐SSEA‐1) which recognizes an early embryonic antigen in the mouse. Until recently this carbohydrate structure was considered to be rare among glycoproteins and glycosphingolipids. However, there is a growing list of human and animal glycoproteins in which this sequence has been detected by chemical and immunochemical methods. In this article we survey this information and discuss how this and other carbohydrate structures behave as differentiation‐ or tumor‐associated antigens.
针对人肺癌细胞系 SK-LC-3 的小鼠单克隆 IgM 抗体，对 H(O) 血型抗原具有特异性。
影响因子：
--
作者：
Anger,BR;Lloyd,KO;Oettgen,HF;Old,LJ
通讯作者：
Old,LJ
影响因子：
20.3
作者：
Ritz,J;Schlossman,SF
通讯作者：
Schlossman,SF