The FAT1 Cadherin Drives Vascular Smooth Muscle Cell Migration.
The FAT1 Cadherin Drives Vascular Smooth Muscle Cell Migration.
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DOI：
10.3390/cells12121621
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发表时间：
2023-06-14
期刊：
影响因子：
6
通讯作者：
Sibinga, Nicholas E. S.
中科院分区：
文献类型：
--
作者：
Riascos-Bernal, Dario F.;Ressa, Gaia;Korrapati, Anish;Sibinga, Nicholas E. S.
关键词：
血管平滑肌细胞（VSMC）通常是静止的和非迁移的，调节血管的收缩和舒张以控制血管张力。在动脉损伤的反应中，这些细胞变得活跃;它们增殖，分泌基质蛋白，并迁移，从而对几种心血管疾病的进展做出重要贡献。VSMC迁移特别支持动脉粥样硬化、基于导管的干预后再狭窄、移植血管病变和动脉瘤形成期间的血管重塑。非典型钙粘蛋白FAT 1在活化的VSMC中强烈表达并促进其迁移。也已经描述了FAT 1在其他细胞类型（包括神经元、成纤维细胞、足细胞和星形胶质细胞祖细胞）的迁移中的积极作用。然而，在癌症生物学中，FAT 1对迁移的影响取决于癌症类型或背景，因为FAT 1抑制或增强癌细胞迁移和侵袭。通过这篇综述，我们描述了FAT 1对细胞迁移的影响以及影响FAT 1依赖性迁移的因素。在VSMC中，这些因子包括血管紧张素II，其激活FAT 1表达和细胞迁移，以及Atrophin家族的蛋白质：Atrophin-1和Atrophin-2的短亚型，其促进VSMC迁移，以及Atrophin-2的长亚型，其对FAT 1依赖性VSMC迁移产生负面影响。
Vascular smooth muscle cells (VSMCs) are normally quiescent and non-migratory, regulating the contraction and relaxation of blood vessels to control the vascular tone. In response to arterial injury, these cells become active; they proliferate, secrete matrix proteins, and migrate, and thereby contribute importantly to the progression of several cardiovascular diseases. VSMC migration specifically supports atherosclerosis, restenosis after catheter-based intervention, transplant vasculopathy, and vascular remodeling during the formation of aneurysms. The atypical cadherin FAT1 is expressed robustly in activated VSMCs and promotes their migration. A positive role of FAT1 in the migration of other cell types, including neurons, fibroblasts, podocytes, and astrocyte progenitors, has also been described. In cancer biology, however, the effect of FAT1 on migration depends on the cancer type or context, as FAT1 either suppresses or enhances cancer cell migration and invasion. With this review, we describe what is known about FAT1’s effects on cell migration as well as the factors that influence FAT1-dependent migration. In VSMCs, these factors include angiotensin II, which activates FAT1 expression and cell migration, and proteins of the Atrophin family: Atrophin-1 and the short isoform of Atrophin-2, which promote VSMC migration, and the long isoform of Atrophin-2, which exerts negative effects on FAT1-dependent VSMC migration.
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FAT1通过影响食管鳞状细胞癌的细胞力学特性抑制细胞迁移和侵袭
影响因子：
4.2
作者：
Hu X;Zhai Y;Shi R;Qian Y;Cui H;Yang J;Bi Y;Yan T;Yang J;Ma Y;Zhang L;Liu Y;Li G;Zhang M;Cui Y;Kong P;Cheng X
通讯作者：
Cheng X
影响因子：
2.7
作者：
Glasco, Derrick M.;Pike, Whitney;Qu, Yibo;Reustle, Lindsay;Misra, Kamana;Di Bonito, Maria;Studer, Michele;Fritzsch, Bernd;Goffinet, Andre M.;Tissir, Fadel;Chandrasekhar, Anand
通讯作者：
Chandrasekhar, Anand
DOI：
10.1083/jcb.200508121
发表时间：
2006-05-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hou R;Liu L;Anees S;Hiroyasu S;Sibinga NE
通讯作者：
Sibinga NE
影响因子：
4.8
作者：
Castillejo-López, C;Arias, WM;Baumgartner, S
通讯作者：
Baumgartner, S
影响因子：
4.6
作者：
Badouel, Caroline;Zander, Mark A.;McNeill, Helen
通讯作者：
McNeill, Helen