Individual- and neighborhood-level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California.
Individual- and neighborhood-level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California.
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DOI：
10.1002/cncr.33861
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发表时间：
2021-12-15
期刊：
影响因子：
6.2
通讯作者：
Kroenke CH
中科院分区：
文献类型：
--
作者：
Aoki RF;Uong SP;Gomez SL;Alexeeff SE;Caan BJ;Kushi LH;Torres JM;Guan A;Canchola AJ;Morey BN;Lin K;Kroenke CH
低社会经济地位（SES）与侵袭性乳腺癌（BC）亚型的风险较高有关，但很少有研究研究探讨了社区水平的社会经济地位（nSES）和个人水平的SES措施的独立影响。这项研究包括来自癌症流行病学队列的5547名被诊断患有侵袭性BC的妇女。使用广义估计方程模型检查nSES（基于收入、贫困、教育、职业、就业、租金和房屋价值的综合评分）和个人水平SES（收入和教育）与BC亚型的相关性：管腔B（LumB B）、Her 2富集（Her 2-e）和三阴性乳腺癌（TNBC）相对于管腔A（LumA）。模型控制了年龄，种族，出生，阶段，从诊断到调查的天数，研究队列，同时控制了nSES和个人水平的SES。在完全校正的模型中，相对于LumA，低nSES与LumB（四分位数1与四分位数4的比值比[OR Q1 vQ 4]，1.31; 95%置信区间[CI]，1.11-1.54;趋势P = 0.005）和TNBC亚型（ORQ 1vQ 4，1.32; 95% CI，1.02-1.71;趋势P = 0.037）显著相关。相反，相对于LumA，个体教育仅与Her 2-e亚型显著相关（高中或以下学历与研究生的比值比为1.68; 95%CI为1.03-2.75;趋势P = 0.030）。个人收入与任何BC亚型均无显著相关性。nSES和个人水平的SES与不同的BC亚型独立相关;具体而言，低nSES和个人水平的教育是相对于LumA更具侵略性的BC亚型的独立预测因子。
Low socioeconomic status (SES) has been associated with a higher risk of aggressive breast cancer (BC) subtypes, but few studies have examined the independent effects of both neighborhood-level socioeconomic status (nSES) and individual-level SES measures. This study included 5547 women from the Pathways and Life After Cancer Epidemiology cohorts who were diagnosed with invasive BC. Generalized estimating equation models were used to examine associations of nSES (a composite score based on income, poverty, education, occupation, employment, rent, and house value) and individual-level SES (income and education) with BC subtypes: luminal B (LumB), Her2-enriched (Her2-e), and triple-negative breast cancer (TNBC) relative to luminal A (LumA). Models controlled for age, race, nativity, stage, days from diagnosis to survey, and study cohort and simultaneously for nSES and individual-level SES. In fully adjusted models, low nSES was significantly associated with the LumB (odds ratio for quartile 1 vs quartile 4 [OR Q1vQ4], 1.31; 95% confidence interval [CI], 1.11–1.54; P for trend = .005) and TNBC subtypes (ORQ1vQ4, 1.32; 95% CI, 1.02–1.71; P for trend = .037) relative to LumA. Conversely, individual education was significantly associated with only the Her2-e subtype (odds ratio for high school degree or less vs postgraduate, 1.68; 95% CI, 1.03–2.75; P for trend = .030) relative to LumA. Individual income was not significantly associated with any BC subtype. nSES and individual-level SES are independently associated with different BC subtypes; specifically, low nSES and individual-level education are independent predictors of more aggressive BC subtypes relative to LumA.
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影响因子：
6.2
作者：
Lund, Mary Jo;Butler, Ebonee N.;Eley, J. William
通讯作者：
Eley, J. William
影响因子：
2.1
作者：
Parise, Carol A.;Bauer, Katrina R.;Caggiano, Vincent
通讯作者：
Caggiano, Vincent
影响因子：
12.7
作者：
Burger, Joanna;Gochfeld, Michael
通讯作者：
Gochfeld, Michael
影响因子：
2.3
作者：
Andaya, Abegail A.;Enewold, Lindsey;Zhu, Kangmin
通讯作者：
Zhu, Kangmin
DOI：
10.1158/1055-9965.epi-20-1055
发表时间：
2021-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Qin B;Babel RA;Plascak JJ;Lin Y;Stroup AM;Goldman N;Ambrosone CB;Demissie K;Hong CC;Bandera EV;Llanos AAM
通讯作者：
Llanos AAM