[(68)Ga]Ga-DO(2)A-(OBu-l-tyr)(2): synthesis, (68)Ga-radiolabeling and in vitro studies of a novel (68)Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET.
[(68)Ga]Ga-DO(2)A-(OBu-l-tyr)(2): synthesis, (68)Ga-radiolabeling and in vitro studies of a novel (68)Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET.
复制标题
[(68)Ga]Ga-DO(2)A-(OBu-l-tyr)(2)：新型 (68)Ga-DO(2)A 的合成、(68)Ga 放射性标记和体外研究
DOI：
10.1016/j.bmcl.2009.05.001
复制
发表时间：
2009
影响因子：
2.7
通讯作者：
F. Roesch
中科院分区：
文献类型：
--
作者：
C. Burchardt;P. Riss;F. Zoller;S. Maschauer;O. Prante;T. Kuwert;F. Roesch
本文报道了新型酪氨酸螯合衍生物[68 Ga]Ga-1，4，7，10-四氮杂环十二烷-1，7-二乙酸-4，10-二-（O-丁基）-1-酪氨酸（[68 Ga] Ga-DO 2A-（OBu-l-tyr）2）的合成、68 Ga标记和体外研究。该方法结合了L-酪氨酸的生物氨基酸转运蛋白靶向特性和通过68 Ge/68 Ga发生器获得68 Ga III的出色可用性。利用F98-胶质母细胞瘤细胞系的体外研究显示，[68 Ga] Ga-DO 2A-（OBu-l-tyr）2的特异性摄取与参比O-（2-[18 F]氟乙基）-1-酪氨酸（FET）的特异性摄取相当。这些有希望的结果表明[68 Ga] Ga-DO 2A-（OBu-l-tyr）2用于通过PET的肿瘤驱动的氨基酸摄取的分子成像的高潜力。
The synthesis,68Ga-labeling and in vitro study of the novel tyrosine chelate derivative [68Ga]Ga-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid-4,10-di-(O-butyl)-l-tyrosine ([68Ga]Ga-DO2A-(OBu-l-tyr)2) as a potential tracer for imaging tumor metabolism by positron emission tomography (PET) is presented. This approach combines the biological amino acid transporter targeting properties of l-tyrosine with the outstanding availability of68GaIIIvia the68Ge/68Ga generator. In vitro studies utilizing the F98-glioblastoma cell line revealed specific uptake of [68Ga]Ga-DO2A-(OBu-l-tyr)2that was comparable to that of the reference O-(2-[18F]fluoroethyl)-l-tyrosine (FET). These promising results indicate a high potential of [68Ga]Ga-DO2A-(OBu-l-tyr)2for molecular imaging of tumor-driven amino acid uptake by PET.
DOI：
10.1177/0148607192016006569
发表时间：
1992-11
期刊：
JPEN. Journal of parenteral and enteral nutrition
影响因子：
--
作者：
W. Souba;A. J. Pacitti
通讯作者：
W. Souba;A. J. Pacitti