Additive effects of social and non-social attention during infancy relate to later autism spectrum disorder.
Additive effects of social and non-social attention during infancy relate to later autism spectrum disorder.
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DOI：
10.1111/desc.12139
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发表时间：
2014-07
影响因子：
3.7
通讯作者：
BASIS Team
中科院分区：
文献类型：
--
作者：
Bedford R;Pickles A;Gliga T;Elsabbagh M;Charman T;Johnson MH;BASIS Team
由于家中有被诊断患有自闭症谱系障碍（ASD）的哥哥或姐姐，对自闭症谱系障碍高风险婴儿的研究新发现表明，那些后来患上自闭症谱系障碍的婴儿在处理具有社会和非社会内容的刺激时，早期就存在障碍。尽管自闭症谱系障碍是由社交沟通障碍以及刻板重复行为来定义的，但大多数关于自闭症谱系障碍的认知理论都假定存在一个单一的潜在因素，该因素在发展过程中对各个领域产生次要影响。这是第一项利用多种风险因素对自闭症谱系障碍高风险兄弟姐妹的发展理论模型进行统计学区分的高风险研究。我们通过对社会和非社会刺激的关注来检验对自闭症谱系障碍结果的预测：在低风险对照组和高风险自闭症谱系障碍婴儿（这些婴儿在3岁时被诊断患有自闭症谱系障碍）13个月大时评估注视跟随和注意力脱离情况。当纳入同一回归模型时，这些13个月时的测量指标独立地预测了3岁时的自闭症谱系障碍结果。数据用累加模型能得到最好的描述，这表明非社会注意力、脱离情况以及由注视跟随所证明的社会注意力对自闭症谱系障碍风险有累积影响。这些数据与那些提出单一潜在因素在早期发展过程中产生连锁效应从而导致自闭症谱系障碍结果的自闭症谱系障碍认知理论相悖，并支持与近期基因和神经生物学证据更相符的自闭症谱系障碍多障碍模型。
Emerging findings from studies with infants at familial high risk for autism spectrum disorder (ASD), owing to an older sibling with a diagnosis, suggest that those who go on to develop ASD show early impairments in the processing of stimuli with both social and non-social content. Although ASD is defined by social-communication impairments and restricted and repetitive behaviours, the majority of cognitive theories of ASD posit a single underlying factor, which over development has secondary effects across domains. This is the first high-risk study to statistically differentiate theoretical models of the development of ASD in high-risk siblings using multiple risk factors. We examined the prediction of ASD outcome by attention to social and non-social stimuli: gaze following and attentional disengagement assessed at 13 months in low-risk controls and high-risk ASD infants (who were subsequently diagnosed with ASD at 3 years). When included in the same regression model, these 13-month measures independently predicted ASD outcome at 3 years of age. The data were best described by an additive model, suggesting that non-social attention, disengagement, and social attention as evidenced by gaze following, have a cumulative impact on ASD risk. These data argue against cognitive theories of ASD which propose that a single underlying factor has cascading effects across early development leading to an ASD outcome, and support multiple impairment models of ASD that are more consistent with recent genetic and neurobiological evidence.
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影响因子：
3.9
作者：
Rozga, Agata;Hutman, Ted;Sigman, Marian
通讯作者：
Sigman, Marian
DOI：
10.1016/s1385-299x(97)00027-5
发表时间：
1997-12-01
期刊：
BRAIN RESEARCH PROTOCOLS
影响因子：
--
作者：
Fischer, B;Gezeck, S;Hartnegg, K
通讯作者：
Hartnegg, K
DOI：
10.1111/j.2044-835x.1991.tb00862.x
发表时间：
1991-03-01
影响因子：
2.3
作者：
BUTTERWORTH, G;JARRETT, N
通讯作者：
JARRETT, N
影响因子：
2.6
作者：
Farroni, T;Massaccesi, S;Johnson, MH
通讯作者：
Johnson, MH
影响因子：
10.5
作者：
Geschwind DH
通讯作者：
Geschwind DH