Fast detection of unexpected sound intensity decrements as revealed by human evoked potentials.
Fast detection of unexpected sound intensity decrements as revealed by human evoked potentials.
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DOI：
10.1371/journal.pone.0028522
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Escera C
中科院分区：
文献类型：
--
作者：
Althen H;Grimm S;Escera C
异常声音的检测是听觉系统的一项重要功能，反映在自动诱发的失配负波(MMN)上，MMN是一种听觉诱发电位，从刺激开始100到250毫秒。最近有研究表明，在人类听觉诱发电位的中间潜伏期反应中，罕见的频率和位置偏差在非常早期的潜伏期会触发比标准声音更负面的反应。动物听觉皮质和皮质下结构中神经元的发现证实了听觉系统的这种快速和早期的能力，当声音特征发生罕见变化时，这些神经元恢复了对标准声音的适应性反应。在这项研究中，我们调查了强度偏差的检测是否也反映在比MMN更短的潜伏期。分析听性脑干反应、中潜伏期反应(MLR)和MMN的听觉诱发电位。除MMN外，强度低于标准刺激的稀有刺激在刺激开始后约24ms时，在从Na分量到Pa分量的转变过程中，在MLR中诱发更负的电位。这一发现，再加上关于频率和位置变化的研究，表明在奇怪的范例中，早期自动检测异常声音是听觉系统的一种普遍属性。
The detection of deviant sounds is a crucial function of the auditory system and is reflected by the automatically elicited mismatch negativity (MMN), an auditory evoked potential at 100 to 250 ms from stimulus onset. It has recently been shown that rarely occurring frequency and location deviants in an oddball paradigm trigger a more negative response than standard sounds at very early latencies in the middle latency response of the human auditory evoked potential. This fast and early ability of the auditory system is corroborated by the finding of neurons in the animal auditory cortex and subcortical structures, which restore their adapted responsiveness to standard sounds, when a rare change in a sound feature occurs. In this study, we investigated whether the detection of intensity deviants is also reflected at shorter latencies than those of the MMN. Auditory evoked potentials in response to click sounds were analyzed regarding the auditory brain stem response, the middle latency response (MLR) and the MMN. Rare stimuli with a lower intensity level than standard stimuli elicited (in addition to an MMN) a more negative potential in the MLR at the transition from the Na to the Pa component at circa 24 ms from stimulus onset. This finding, together with the studies about frequency and location changes, suggests that the early automatic detection of deviant sounds in an oddball paradigm is a general property of the auditory system.
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