Contextual drive of neuronal responses in mouse V1 in the absence of feedforward input.
Contextual drive of neuronal responses in mouse V1 in the absence of feedforward input.
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DOI：
10.1126/sciadv.add2498
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发表时间：
2023-01-20
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
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初级视皮层（V1）中的神经元对它们的感受野（RF）中的刺激做出反应，该感受野由来自视网膜的前馈输入定义。然而，V1神经元对RF之外的上下文信息也很敏感，即使RF本身没有受到刺激。在这里，我们研究了皮质电路V1上下文响应叠加在不同背景上的灰色磁盘。背景反应开始晚，最强的反馈受体层的V1。他们之间的三个主要类别的抑制性神经元，特别是强大的上下文驱动的VIP神经元，表明上下文驱动的去抑制电路的贡献。当灰色圆盘被感知为图形时，背景驱动力最强，遮蔽了背景，而不是一个洞。我们的研究结果链接上下文驱动V1知觉组织，并提供了以前未知的洞察如何经常性的处理形状的感觉神经元的反应，以促进数字感知。不影响经典RF的刺激激活V1取决于视觉场景的感知解释。
Neurons in the primary visual cortex (V1) respond to stimuli in their receptive field (RF), which is defined by the feedforward input from the retina. However, V1 neurons are also sensitive to contextual information outside their RF, even if the RF itself is unstimulated. Here, we examined the cortical circuits for V1 contextual responses to gray disks superimposed on different backgrounds. Contextual responses began late and were strongest in the feedback-recipient layers of V1. They differed between the three main classes of inhibitory neurons, with particularly strong contextual drive of VIP neurons, indicating a contribution of disinhibitory circuits to contextual drive. Contextual drive was strongest when the gray disk was perceived as figure, occluding its background, rather than a hole. Our results link contextual drive in V1 to perceptual organization and provide previously unknown insight into how recurrent processing shapes the response of sensory neurons to facilitate figure perception. V1 activation by stimuli that don’t impinge on the classical RF depends on the perceptual interpretation of the visual scene.
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DOI：
10.1126/science.aac9462
发表时间：
2015-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang X;Shen S;Cadwell CR;Berens P;Sinz F;Ecker AS;Patel S;Tolias AS
通讯作者：
Tolias AS
影响因子：
25
作者：
Lee, Soohyun;Kruglikov, Illya;Huang, Z. Josh;Fishell, Gord;Rudy, Bernardo
通讯作者：
Rudy, Bernardo
影响因子：
64.8
作者：
DEWEERD, P;GATTASS, R;UNGERLEIDER, LG
通讯作者：
UNGERLEIDER, LG
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ
DOI：
10.1007/bf00318224
发表时间：
1988-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
HAJOS, F;ZILLES, K;KALMAN, M
通讯作者：
KALMAN, M