Noninvasive indices of autonomic regulation after alprazolam and lorazepam: effects on sympathovagal balance.
Noninvasive indices of autonomic regulation after alprazolam and lorazepam: effects on sympathovagal balance.
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阿普唑仑和劳拉西泮后自主神经调节的无创指数：对交感迷走神经平衡的影响。
DOI：
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发表时间：
1998
影响因子：
3
通讯作者：
A. Man In't Veld
中科院分区：
文献类型：
--
作者：
J. Tulen;A. Man In't Veld
皮肤电导水平（SCL）和频谱分析的心率（HR）和血压（BP）的变化，血浆中的儿茶酚胺浓度，用于评估自主神经系统的活动，在仰卧位休息的情况下，口服阿普唑仑1 mg和劳拉西泮2 mg后4 h内。12名健康男性采用双盲、随机交叉设计，在不同日期接受1 mg阿普唑仑或2 mg劳拉西泮或安慰剂。每次治疗期间连续监测ECG、BP、呼吸和SCL。对于HR、收缩压和舒张压（SBP、DBP）时间序列，在给药后30分钟、1小时和45分钟以及3小时每5分钟计算一次功率谱，持续三个15分钟时间段。评估了三个频带的谱功率：低（0.02-0.06 Hz）、中（0.07-0.14 Hz）和高（0.15-0.50 Hz）。每个时间段，收缩压值和RR间期之间的中频带的增益被计算为压力反射敏感性（BRS）指数。每15分钟后采集血样测定血浆儿茶酚胺。阿普唑仑在整个记录期间降低DBP;与安慰剂相比，该效应伴随着30 min时BP中频带波动的初始增加，随后在给药后1 h、45 min和3 h降低（表明初始反射增加，随后交感神经张力减弱）。BP效应伴随着血浆去甲肾上腺素浓度的降低。阿普唑仑给药后HR呈时间依赖性降低，HR和BRS的高频带波动增加（表明心脏迷走神经张力呈时间依赖性增加）。阿普唑仑治疗后SCL下降。劳拉西泮对HR无时间依赖性降低，对血压无影响，但可增加HR和DBP的低频功率，轻度降低SCL。阿普唑仑和劳拉西泮对呼吸频率无影响。自主神经调节的非侵入性指标显示，1 mg阿普唑仑对交感神经和副交感神经过程有几个小的，但显着的，时间依赖性的影响，而对于2 mg劳拉西泮，这些影响不太清楚。阿普唑仑给药后交感神经张力的非侵入性指数的降低与阿普唑仑对血浆去甲肾上腺素浓度的衰减相对应。
Skin conductance level (SCL) and spectral analysis of variations in heart rate (HR) and blood pressure (BP), in relation to plasma catecholamine concentrations, were used to evaluate autonomic nervous system activity during situations of supine rest within a period of 4 h after oral administration of 1 mg alprazolam and 2 mg lorazepam. Twelve healthy men received in a double-blind, randomized crossover design, either 1 mg alprazolam, or 2 mg lorazepam, or a placebo on different days. ECG, BP, respiration, and SCL were monitored continuously during each session. For HR, systolic and diastolic BP (SBP, DBP) time series, power spectra were calculated per 5 min for three 15-min periods at 30 min, 1 h and 45 min, and 3 h after dosing. Spectral power was assessed for three frequency bands: low (0.02-0.06 Hz), mid (0.07-0.14 Hz), and high (0.15-0.50 Hz). Per time segment, the gain in the mid-frequency band between the systolic BP values and the RR interval times was computed as index of baroreflex sensitivity (BRS). Blood samples for assay of plasma catecholamines were obtained after each 15-min period. Alprazolam reduced DBP during the whole recording period; the effect was accompanied by an initial increase of mid-frequency band fluctuations of BP at 30 min, which subsequently decreased at 1 h 45 min and 3 h after dose administration, in comparison with placebo (suggesting an initial reflectory increase, followed by an attenuation of sympathetic tone). The BP effects were accompanied by a reduction of plasma noradrenaline concentrations. HR showed a time-dependent decrease after alprazolam and an increase in high-frequency band fluctuations of HR and BRS (suggesting a time-dependent increase in cardiac vagal tone). SCL was decreased after alprazolam administration. Lorazepam did not show a time-dependent reduction of HR and had no effect on BP, but increased low-frequency band power of HR and DBP and mildly reduced SCL. Alprazolam and lorazepam had no effect on respiratory frequency. Noninvasive indices of autonomic regulation revealed several small, but significant, time-dependent effects of 1 mg alprazolam on sympathetic and parasympathetic processes, whereas for 2 mg lorazepam, these effects were less clear. The reduction in noninvasive indices of sympathetic tone after alprazolam administration corresponded with the attenuation of plasma noradrenaline concentrations by alprazolam.
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
GABA能机制在动脉压的中枢调节中的作用。
影响因子：
39.3
作者：
DiMicco,JA;Abshire,VM;Shekhar,A;WilbeJr,JH
通讯作者：
WilbeJr,JH