Ferroptosis as a potential target for cancer therapy.
Ferroptosis as a potential target for cancer therapy.
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DOI：
10.1038/s41419-023-05930-w
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发表时间：
2023-07-24
影响因子：
9
通讯作者：
Li, Xiumin
中科院分区：
文献类型：
--
作者：
Chen, Zhen;Wang, Weilong;Abdul Razak, Siti Razila;Han, Tao;Ahmad, Nor Hazwani;Li, Xiumin
铁死亡是最近发现的一种重要的细胞死亡类型，其主要特征是铁过载和脂质过氧化。新的证据表明，铁死亡是人类癌症的一把双刃剑。然而，确切的潜在分子机制及其在肿瘤发生中的不同作用尚不清楚。因此，在这篇综述中，我们总结并简要介绍了铁死亡的关键途径，特别关注铁死亡的调节及其在各种人类癌症中作为致癌事件和抑癌事件的双重作用。此外，还总结了多种药理铁死亡激活剂，进一步阐明了靶向铁死亡在癌症治疗中的前景。
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
24.1
作者：
Bertheloot D;Latz E;Franklin BS
通讯作者：
Franklin BS
影响因子：
24.5
作者：
Brookes, M. J.;Hughes, S.;Tselepis, C.
通讯作者：
Tselepis, C.