Genetic Influence on Quantitative Features of Neocortical Architecture

Genetic Influence on Quantitative Features of Neocortical Architecture
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遗传对新皮质结构数量特征的影响

DOI:
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发表时间:
2002
影响因子:
5.3
通讯作者:
S. Löwel
S. Löwel
中科院分区:
医学1区
文献类型:
--
作者:
M. Kaschube;F. Wolf;T. Geisel;S. Löwel

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功能性皮层地图的布局表现出高度的个体间变异性,这可能解释了感觉和认知能力的个体差异。通过定量评估的个体间变异的方向偏好列在初级视觉皮层,我们表明,列的大小和形状,以及测量的均匀性列大小的视觉皮层显着聚集在遗传相关的动物和在两个半球的个人大脑。考虑到柱形成的发展时间表,我们的数据表明,大量的遗传影响的视觉皮层架构的发展规格,并建议遗传信息可能会影响个人的视觉能力的方式。
The layout of functional cortical maps exhibits a high degree of interindividual variability that may account for individual differences in sensory and cognitive abilities. By quantitatively assessing the interindividual variability of orientation preference columns in the primary visual cortex, we demonstrate that column sizes and shapes as well as a measure of the homogeneity of column sizes across the visual cortex are significantly clustered in genetically related animals and in the two hemispheres of individual brains. Taking the developmental timetable of column formation into account, our data indicate a substantial genetic influence on the developmental specification of visual cortical architecture and suggest ways in which genetic information may influence an individual's visual abilities.
DOI: 10.1126/science.279.5350.566
发表时间: 1998-01-23
期刊: SCIENCE
影响因子: 56.9
作者:
Crair, MC;Gillespie, DC;Stryker, MP
通讯作者: Stryker, MP