T cell immune memory after covid-19 and vaccination.
T cell immune memory after covid-19 and vaccination.
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DOI：
10.1136/bmjmed-2022-000468
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Payne, Rebecca P.
中科院分区：
文献类型：
--
作者：
Wang, Lulu;Nicols, Alex;Turtle, Lance;Richter, Alex;Duncan, Christopher J. A.;Dunachie, Susanna J.;Klenerman, Paul;Payne, Rebecca P.
T细胞记忆反应是适应性免疫的重要组成部分，负责限制或预防病毒再感染。感染SARS-CoV-2病毒或接种疫苗后的T细胞记忆是广泛的，并且跨越多种病毒蛋白和表位，每个个体中约有20个。到目前为止，T细胞记忆反应是持久的，并提供了高水平的交叉反应性，因此对SARS-CoV-2病毒变体（如omicron变体）的病毒逃逸具有抗性。所有目前测试的疫苗方案产生强大的T细胞记忆应答，异源方案可能会通过增加广度来增强保护性应答。T细胞记忆可能通过快速清除病毒和早期呈递表位，在预防严重的COVID-19疾病方面发挥重要作用，交叉反应性T细胞的存在可能会增强这种保护作用。T细胞记忆可能会提供持续的保护，防止入院和死亡，而泛冠状病毒疫苗的开发可能会在未来证明对新的大流行毒株。
The T cell memory response is a crucial component of adaptive immunity responsible for limiting or preventing viral reinfection. T cell memory after infection with the SARS-CoV-2 virus or vaccination is broad, and spans multiple viral proteins and epitopes, about 20 in each individual. So far the T cell memory response is long lasting and provides a high level of cross reactivity and hence resistance to viral escape by variants of the SARS-CoV-2 virus, such as the omicron variant. All current vaccine regimens tested produce robust T cell memory responses, and heterologous regimens will probably enhance protective responses through increased breadth. T cell memory could have a major role in protecting against severe covid-19 disease through rapid viral clearance and early presentation of epitopes, and the presence of cross reactive T cells might enhance this protection. T cell memory is likely to provide ongoing protection against admission to hospital and death, and the development of a pan-coronovirus vaccine might future proof against new pandemic strains.
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影响因子：
56.3
作者：
Bobrovitz, Niklas;Ware, Harriet;Ma, Xiaomeng;Li, Zihan;Hosseini, Reza;Cao, Christian;Selemon, Anabel;Whelan, Mairead;Premji, Zahra;Issa, Hanane;Cheng, Brianna;Abu Raddad, Laith J.;Buckeridge, David L.;Van Kerkhove, Maria D.;Piechotta, Vanessa;Higdon, Melissa M.;Wilder-Smith, Annelies;Bergeri, Isabel;Feikin, Daniel R.;Arora, Rahul K.;Patel, Minal K.;Subissi, Lorenzo
通讯作者：
Subissi, Lorenzo
影响因子：
7.3
作者：
通讯作者：
--
影响因子：
64.5
作者：
Arieta, Christina M.;Xie, Yushu Joy;Rothenberg, Daniel A.;Diao, Huitian;Harjanto, Dewi;Meda, Shirisha;Marquart, Krisann;Koenitzer, Byron;Sciuto, Tracey E.;Lobo, Alexander;Zuiani, Adam;Krumm, Stefanie A.;Couto, Carla Iris Cadima;Hein, Stephanie;Heinen, Andre P.;Ziegenhals, Thomas;Liu-Lupo, Yunpeng;Vogel, Annette B.;Srouji, John R.;Fesser, Stephanie;Thanki, Kaushik;Walzer, Kerstin;Addona, Theresa A.;Tureci, Ozlem;Sahin, Ugur;Gaynor, Richard B.;Poran, Asaf
通讯作者：
Poran, Asaf
影响因子：
30.5
作者：
Brasu, Nadia;Elia, Ines;Pace, Luigia
通讯作者：
Pace, Luigia
影响因子：
24.8
作者：
Cheon IS;Li C;Son YM;Goplen NP;Wu Y;Cassmann T;Wang Z;Wei X;Tang J;Li Y;Marlow H;Hughes S;Hammel L;Cox TM;Goddery E;Ayasoufi K;Weiskopf D;Boonyaratanakornkit J;Dong H;Li H;Chakraborty R;Johnson AJ;Edell E;Taylor JJ;Kaplan MH;Sette A;Bartholmai BJ;Kern R;Vassallo R;Sun J
通讯作者：
Sun J