Immune signatures underlying post-acute COVID-19 lung sequelae.
Immune signatures underlying post-acute COVID-19 lung sequelae.
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DOI：
10.1126/sciimmunol.abk1741
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发表时间：
2021-11-12
影响因子：
24.8
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Cheon IS;Li C;Son YM;Goplen NP;Wu Y;Cassmann T;Wang Z;Wei X;Tang J;Li Y;Marlow H;Hughes S;Hammel L;Cox TM;Goddery E;Ayasoufi K;Weiskopf D;Boonyaratanakornkit J;Dong H;Li H;Chakraborty R;Johnson AJ;Edell E;Taylor JJ;Kaplan MH;Sette A;Bartholmai BJ;Kern R;Vassallo R;Sun J
呼吸道组织常驻样CD8+T细胞与新冠肺炎急性发作后的慢性肺部后遗症有关。严重冠状病毒病2019(新冠肺炎)肺炎幸存者通常会出现长期的肺部后遗症，但其潜在机制或相关的局部和系统免疫相关尚不清楚。在这里，我们对老年新冠肺炎康复期患者的病理生理和免疫特征进行了高维表征，并将局部和系统免疫特征与肺功能和肺成像相关联。我们发现慢性肺损伤伴随着持续性的呼吸道免疫改变。我们发现，与血液相比，功能性严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)特异性记忆T细胞和B细胞在感染部位得到了丰富。对肺免疫功能的详细评估表明，呼吸系统CD8+T细胞反应异常与急性新冠肺炎后肺功能受损有关。单细胞转录分析确定了呼吸道CD8+T细胞的潜在致病亚群，这些亚群与新冠肺炎后持续的组织状况有关。我们的结果揭示了可能支持老年人SARS-CoV-2肺炎后肺部后遗症发展的病理生理和免疫特征，并对慢性新冠肺炎症状的治疗具有指导意义。
Respiratory tissue resident–like CD8+ T cells are associated with chronic lung sequelae post-acute COVID-19. Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term pulmonary sequelae, but the underlying mechanisms or associated local and systemic immune correlates are not known. Here, we have performed high-dimensional characterization of the pathophysiological and immune traits of aged COVID-19 convalescents, and correlated the local and systemic immune profiles with pulmonary function and lung imaging. We found that chronic lung impairment was accompanied by persistent respiratory immune alterations. We showed that functional severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific memory T and B cells were enriched at the site of infection compared with those of blood. Detailed evaluation of the lung immune compartment revealed that dysregulated respiratory CD8+ T cell responses were associated with the impaired lung function after acute COVID-19. Single-cell transcriptomic analysis identified the potential pathogenic subsets of respiratory CD8+ T cells contributing to persistent tissue conditions after COVID-19. Our results have revealed pathophysiological and immune traits that may support the development of lung sequelae after SARS-CoV-2 pneumonia in older individuals, with implications for the treatment of chronic COVID-19 symptoms.
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影响因子：
8.8
作者：
Neidleman J;Luo X;George AF;McGregor M;Yang J;Yun C;Murray V;Gill G;Greene WC;Vasquez J;Lee SA;Ghosn E;Lynch KL;Roan NR
通讯作者：
Roan NR
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
2.3
作者：
Bates, JHT;Lutchen, KR
通讯作者：
Lutchen, KR
影响因子：
64.8
作者：
Dudek, Michael;Pfister, Dominik;Knolle, Percy A.
通讯作者：
Knolle, Percy A.
影响因子：
3.3
作者：
Hantos, Z;Petak, F;Fredberg, JJ
通讯作者：
Fredberg, JJ