Characterization of a monoclonal antibody that reacts with an activation antigen on human B cells: reactions on mitogen-stimulated blood lymphocytes and cells of normal lymph nodes.
Characterization of a monoclonal antibody that reacts with an activation antigen on human B cells: reactions on mitogen-stimulated blood lymphocytes and cells of normal lymph nodes.
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与人 B 细胞上的激活抗原发生反应的单克隆抗体的表征：对有丝分裂原刺激的血液淋巴细胞和正常淋巴结细胞的反应。
DOI：
10.1182/blood.v62.6.1224.1224
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
S. Baird
中科院分区：
文献类型：
--
作者：
D. Frisman;S. Slovin;I. Royston;S. Baird
我们描述了一种与人b淋巴样细胞反应的单克隆抗体。我们已经描述了这种抗体在正常血液淋巴细胞上的反应，有和没有商陆有丝分裂原刺激，骨髓淋巴细胞，和正常淋巴结的冷冻切片。这种名为B532的抗体似乎能识别人类B细胞上的一种活化抗原。这种活化抗原显然可以通过eb病毒感染和抗原和有丝分裂原刺激诱导，但在浆细胞上丢失。在正常的淋巴结中，抗原局限于生发中心细胞和围绕生发中心的“套”的一些细胞。抗原不存在于T细胞上。
We describe a monoclonal antibody that reacts with human B-lymphoid cells. We have characterized the reactions of this antibody on normal blood lymphocytes, with and without pokeweed mitogen stimulation, bone marrow lymphocytes, and on frozen sections of normal lymph nodes. The antibody, B532, appears to recognize an activation antigen on human B cells. This activation antigen can apparently be induced both by infection with Epstein-Barr virus and by stimulation with antigens and mitogens, but it is lost on plasma cells. In normal lymph nodes, the antigen is confined to germinal center cells and some of the cells of the "mantle" that surrounds germinal centers. The antigen is not present on T cells.
单克隆抗体识别感染 Epstein-Barr 病毒的人 B 细胞上的膜抗原。
DOI：
10.1073/pnas.79.8.2649
发表时间：
1982
影响因子：
11.1
作者：
Slovin,SF;Frisman,DM;Tsoukas,CD;Royston,I;Baird,SM;Wormsley,SB;Carson,DA;Vaughan,JH
通讯作者：
Vaughan,JH