Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19).
Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19).
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DOI：
10.1007/s00415-021-10406-y
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发表时间：
2021-09
影响因子：
6
通讯作者：
Yoo HJ
中科院分区：
文献类型：
--
作者：
Harapan BN;Yoo HJ
严重急性呼吸综合征冠状病毒2型是一种新型冠状病毒，是导致19型冠状病毒病(新冠肺炎)暴发的罪魁祸首，于2019年12月在武汉首次发现中国。显而易见，新冠肺炎大流行已成为一个具有挑战性的世界性问题。虽然大多数新冠肺炎患者主要出现呼吸道症状，但也观察到越来越多的与新冠肺炎相关的神经系统症状和表现。在这篇叙述性综述中，我们详细阐述了已提出的新冠肺炎的神经营养机制和目前文献中报道的各种神经症状、表现和并发症。为此，我们回顾了目前已发表的所有文献(研究、病例报告、病例系列、综述、社论和其他文章)，并总结了新冠肺炎的神经学后遗症。基本的和常见的神经系统症状，包括味觉和嗅觉功能障碍，肌肉疼痛，头痛，精神状态改变，神志不清和头晕目眩，将在不同的部分单独介绍。此外，还系统地讨论了中风、脑(窦)静脉血栓形成、癫痫发作、脑膜脑炎、格林-巴利综合征、Miller-Fisher综合征、急性脊髓炎和后部可逆性脑病综合征(PRES)等备受关注的神经系统表现和并发症。未来需要研究神经系统症状和表现对病程的影响，以进一步澄清和评估神经系统并发症与新冠肺炎患者临床结果之间的联系。为了限制长期后果，至关重要的是，医护人员能够及早发现可能的神经症状，并精通新冠肺炎日益常见的神经表现和并发症。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is responsible for the outbreak of coronavirus disease 19 (COVID-19) and was first identified in Wuhan, China in December 2019. It is evident that the COVID-19 pandemic has become a challenging world issue. Although most COVID-19 patients primarily develop respiratory symptoms, an increasing number of neurological symptoms and manifestations associated with COVID-19 have been observed. In this narrative review, we elaborate on proposed neurotropic mechanisms and various neurological symptoms, manifestations, and complications of COVID-19 reported in the present literature. For this purpose, a review of all current published literature (studies, case reports, case series, reviews, editorials, and other articles) was conducted and neurological sequelae of COVID-19 were summarized. Essential and common neurological symptoms including gustatory and olfactory dysfunctions, myalgia, headache, altered mental status, confusion, delirium, and dizziness are presented separately in sections. Moreover, neurological manifestations and complications that are of great concern such as stroke, cerebral (sinus) venous thrombosis, seizures, meningoencephalitis, Guillain–Barré syndrome, Miller Fisher syndrome, acute myelitis, and posterior reversible encephalopathy syndrome (PRES) are also addressed systematically. Future studies that examine the impact of neurological symptoms and manifestations on the course of the disease are needed to further clarify and assess the link between neurological complications and the clinical outcome of patients with COVID-19. To limit long-term consequences, it is crucial that healthcare professionals can early detect possible neurological symptoms and are well versed in the increasingly common neurological manifestations and complications of COVID-19.
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影响因子：
13.6
作者：
通讯作者：
--
DOI：
10.1007/s42451-020-00191-9
发表时间：
2020-05-11
期刊：
DGNeurologie
影响因子：
--
作者：
Bösel J;Berlit P
通讯作者：
Berlit P
影响因子：
8.4
作者：
Bagnato, Sergio;Boccagni, Cristina;Rubino, Francesca
通讯作者：
Rubino, Francesca
影响因子：
8.8
作者：
Anand, Pria;Zakaria, Asma;Cervantes-Arslanian, Anna M.
通讯作者：
Cervantes-Arslanian, Anna M.
影响因子：
2.4
作者：
Al-olama, Mohammad;Rashid, Anas;Garozzo, Debora
通讯作者：
Garozzo, Debora