Synthetic genetic circuits in crop plants.

Synthetic genetic circuits in crop plants.
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DOI:
10.1016/j.copbio.2017.07.003
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发表时间:
2018-03
影响因子:
7.7
通讯作者:
Nemhauser J
Nemhauser J
中科院分区:
工程技术1区
文献类型:
--
作者:
de Lange O;Klavins E;Nemhauser J

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作物育种和遗传学之间的恋情始于一个多世纪前,并一直有增无减,从大规模选择计划到定向操纵基因组的最新技术。将调控序列和编码序列结合在一起的遗传电路可以加速作物改良。在不久的将来,复杂的特征可以从遗传成分中合理地设计出来,并直接传递到感兴趣的基因组中。然而,从探索性实验室测试到作物试验还没有一条标准化的管道,将转基因产品推向市场仍然是一个相当大的障碍。我们强调到目前为止的成功和未来的发展,使基因电路成为本世纪可行的作物改良技术所必需的。
The love affair between crop breeding and genetics began over a century ago and has continued unabated, from mass selection programs up to the latest techniques for targeted manipulation of genomes. Genetic circuits, combining both regulatory and coding sequences, could accelerate crop improvement. In the near future, complex traits could be rationally designed from genetic components and delivered directly to a genome of interest. However, there is not yet a standardized pipeline from exploratory laboratory testing to crop trials, and bringing transgenic products to market remains a considerable barrier. We highlight successes so far and future developments necessary to make genetic circuits a viable crop improvement technology over this century.
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